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Plasma levels of platinum-induced fatty acid [16:4n-3] do not affect response to platinum-based chemotherapy: A pilot study in non-small cell lung cancer patients
- Source :
- Clinical nutrition ESPEN. 40
- Publication Year :
- 2020
-
Abstract
- Summary Background & aims Pre-clinical studies suggest that 16:4(n-3) in purified form or as a component of fish oil might induce platinum-based chemotherapy resistance. Our aim was to determine plasma total and free 16:4(n-3) before and during platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients supplemented with fish oil or provided standard care, and to explore relationships between plasma 16:4(n-3) levels and tumor response to treatment. Methods In a retrospective, secondary data analysis of a prior clinical trial, plasma from patients with NSCLC (n = 21) who underwent platinum-based chemotherapy and were assigned to 2.2 g/day of eicosapentaenoic (EPA) plus 1.1 g DHA/day as fish oil (FO; n = 12) or received no intervention (standard care; SC; n = 9). Plasma 16:4(n-3) was quantified as free and esterified (total) fatty acid using HPLC-MS/MS. Plasma 16:4(n-3) levels were evaluated over time in relation to fish oil supplementation and response to platinum-based therapy, and compared with a group of healthy subjects (REF; n = 11). Results Plasma 16:4(n-3) was detected in all samples. The percentage change/day in plasma esterified (total) 16:4(n-3) was higher for FO versus SC group (2.7 versus −1.8%/d, U = 20, p = 0.02), but change in plasma free 16:4(n-3) was not different between FO and SC. Median plasma free and esterified 16:4(n-3) were similar between responders and non-responders to platinum-based chemotherapy. Total and free plasma 16:4(n-3) fatty acids were similar between NSCLC patients and REF (NSCLC vs REF: total 16:4(n-3): 122.9 vs. 95.2 nM and free 16:4(n-3) 23.9 vs. 27.6 nM). Conclusions This first of its kind study that evaluated plasma 16:4(n-3) in NSCLC patients showed that 16:4 (n-3) was elevated during FO supplementation, independent of fish oil supplementation or platinum-based chemotherapy.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Lung Neoplasms
Docosahexaenoic Acids
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
chemistry.chemical_element
030209 endocrinology & metabolism
Pilot Projects
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Tandem Mass Spectrometry
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Lung cancer
Platinum
Retrospective Studies
chemistry.chemical_classification
Chemotherapy
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Fatty Acids
Fatty acid
Plasma levels
medicine.disease
Fish oil
3. Good health
chemistry
Eicosapentaenoic Acid
Non small cell
business
Chemotherapy resistance
Subjects
Details
- ISSN :
- 24054577
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Clinical nutrition ESPEN
- Accession number :
- edsair.doi.dedup.....53dfbacce0c16bea893020e017f602a8