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Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain
- Source :
- The Journal of Steroid Biochemistry and Molecular Biology. 40:133-142
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- The mechanisms involved in the physiology of the secretion of ACTH are reviewed. The secretion is regulated by the biological consequences of the occupancy of high affinity mineralocorticoid (MR) and lower affinity glucocorticoid receptors (GR) for corticosterone at specific sites of the rat brain. The regulation by this mechanism of basal secretion during the circadian rhythm, the effect of adrenalectomy and of corticosterone replacement is discussed. Experiments with RU486, a specific glucocorticoid antagonist, suggest that occupancy of both MR and GR is required for normal control of ACTH at the time of peak activity. The occupancy of the GR for a few hours per day apparently suffices to maintain steady levels of the products of GR-responsive genes throughout the body.
- Subjects :
- Receptors, Steroid
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Biology
Biochemistry
chemistry.chemical_compound
Receptors, Glucocorticoid
Endocrinology
Glucocorticoid receptor
Adrenocorticotropic Hormone
Corticosterone
Mineralocorticoids
Internal medicine
Adrenal Glands
medicine
Animals
Secretion
Receptor
Molecular Biology
Adrenalectomy
Brain
Cell Biology
Circadian Rhythm
Rats
Steroid hormone
Receptors, Mineralocorticoid
chemistry
Mineralocorticoid
Molecular Medicine
hormones, hormone substitutes, and hormone antagonists
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 09600760
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- The Journal of Steroid Biochemistry and Molecular Biology
- Accession number :
- edsair.doi.dedup.....53f47de8e46aedd902aa39317bbc897f
- Full Text :
- https://doi.org/10.1016/0960-0760(91)90176-6