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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
- Source :
- Bioorganic & Medicinal Chemistry Letters. 22:7376-7380
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.
- Subjects :
- Olanzapine
medicine.medical_specialty
Clinical Biochemistry
Administration, Oral
Pharmaceutical Science
Pharmacology
Weight Gain
Biochemistry
Rats, Sprague-Dawley
Benzodiazepines
Structure-Activity Relationship
chemistry.chemical_compound
Receptors, Glucocorticoid
In vivo
Internal medicine
Drug Discovery
medicine
Animals
Structure–activity relationship
Receptor
Molecular Biology
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Antiglucocorticoid
Organic Chemistry
Antagonist
Rats
Dose–response relationship
Endocrinology
Models, Animal
Molecular Medicine
medicine.symptom
Weight gain
Thymine
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....541110052c7b57a2ea48db89fe09a186
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.10.074