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A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
- Source :
- eLife, Vol 8 (2019), eLife, eLife, eLife Sciences Publication, 2019, 8, pp.e47460. ⟨10.7554/eLife.47460⟩, eLife, 2019, 8, pp.e47460. ⟨10.7554/eLife.47460⟩
- Publication Year :
- 2019
- Publisher :
- eLife Sciences Publications, Ltd, 2019.
-
Abstract
- International audience; In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of esophagus muscle progenitors, where Hgf ligand is expressed in adjacent smooth muscle cells. These observations highlight the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
- Subjects :
- Mouse
Tbx1-Isl1-Met/HGF
[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Mesoderm
Mice
0302 clinical medicine
SKELETAL MYOGENESIS
Biology (General)
[SDV.BDD]Life Sciences [q-bio]/Development Biology
0303 health sciences
Hepatocyte Growth Factor
Myogenesis
General Neuroscience
C-MET RECEPTOR
1184 Genetics, developmental biology, physiology
Gene Expression Regulation, Developmental
General Medicine
Proto-Oncogene Proteins c-met
Cell biology
DIFFERENTIATION
medicine.anatomical_structure
Medicine
MOUSE ESOPHAGUS
Signal Transduction
Research Article
EXPRESSION
TBX1
GROWTH-FACTOR
QH301-705.5
PHARYNGEAL ARCH
Science
LIM-Homeodomain Proteins
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Esophagus
REVEALS
[SDV.BDD] Life Sciences [q-bio]/Development Biology
myogenic migration
medicine
Animals
HEAD
Body Patterning
030304 developmental biology
Progenitor
Evolutionary Biology
General Immunology and Microbiology
antero-posterior patterning
cardiopharyngeal mesoderm
Skeletal muscle
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Muscle, Striated
PROGENITOR CELLS
esophagus striated muscles
ISL1
T-Box Domain Proteins
030217 neurology & neurosurgery
Pharyngeal arch
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....541ecffbb77be5014637e1776f098e99