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Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease
- Source :
- NEUROCHEMISTRY INTERNATIONAL, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
- Publication Year :
- 2019
-
Abstract
- Alzheimer Disease (AD) is a pathology that causes millions of deaths every year and it also generates severe economic consequences for families and public health systems. Oxidative stress is related to neurodegenerative diseases damage. In fact, brain lipid oxidation could produce brain atrophy. The main objective of this study is the evaluation of atrophy and lipid peroxidation damage in AD patients. We studied medial temporal brain atrophy by magnetic resonance imaging (MRI) and a set of lipid peroxidation biomarkers from plasma samples, respectively. The participants were AD patients in early stages (n = 80) and healthy controls (n = 32). Some lipid peroxidation compounds (neuroprostanes, isoprostanes, neurofurans, isofurans, 17-epi-17-F2t-dihomo-IsoP, PGF2α) in plasma showed statistically significant correlation with medial temporal atrophy. So, they were selected to generate an AD diagnosis model, showing an AUC-ROC of 0.900, close to accuracy achieved by the model based on neuroimaging analysis (AUC-ROC 0.929). In addition, the new model showed suitable specificity, so it could be used as screening test. The developed model based on plasma biomarkers could reflect white and grey matter lipid peroxidation, which occurs in medial temporal lobe in early AD patients. Nevertheless, more studies are needed in this field in order to evaluate specificity against other dementias or neurodegenerative diseases.
- Subjects :
- 0301 basic medicine
Male
Pathology
Isoprostanes
medicine.disease_cause
Lipid peroxidation
chemistry.chemical_compound
0302 clinical medicine
Medicine
Gray Matter
Aged, 80 and over
Neurodegeneration
Middle Aged
Magnetic Resonance Imaging
White Matter
Temporal Lobe
medicine.anatomical_structure
Area Under Curve
Female
Alzheimer's disease
Alzheimer disease
medicine.medical_specialty
Neuroimaging
Grey matter
Temporal lobe
03 medical and health sciences
Cellular and Molecular Neuroscience
Atrophy
Alzheimer Disease
Humans
Plasma biomarkers
Furans
Aged
business.industry
Cell Biology
medicine.disease
Oxidative Stress
030104 developmental biology
chemistry
ROC Curve
Oxidative stress
Neuroprostanes
Neuroimage
Lipid Peroxidation
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 18729754 and 01970186
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Neurochemistry international
- Accession number :
- edsair.doi.dedup.....542e7c90598a5bca4a048a9ac2a077fc