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PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua
- Source :
- Mucosal Immunology, Mucosal Immunology, Nature Pub. Group, 2019, 12 (3), pp.624-631. ⟨10.1038/s41385-019-0141-9⟩, Mucosal Immunology, 2019, 12 (3), pp.624-631. ⟨10.1038/s41385-019-0141-9⟩
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- International audience; Group 3 innate lymphoid cells (ILC3) have been detected in both murine and human decidual tissues where they are thought to play a relevant role in the induction and maintenance of pregnancy. However, limited information exists on the molecular mechanisms that regulate these cells, including immune checkpoints. Here, we show that ILC3 express the inhibitory checkpoints programmed cell death (PD-1) and T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) during the first trimester of pregnancy and that these receptors could regulate production of cytokines, including IL-22, IL-8, and TNF-α, induced by IL-23. We also show that the intermediate extravillous trophoblast (iEVT) expresses high levels of the PD-1-ligand PD-L1, suggesting that PD-1/PD-L1 interaction may regulate ILC3 function at the feto-maternal interface. Our present data provide the first evidence that human decidual ILC3 express a functional PD-1. It is possible that an altered expression or function of PD-1 may break the immune-tolerance resulting in pregnancy failure.
- Subjects :
- MESH: Signal Transduction
0301 basic medicine
MESH: Trophoblasts
[SDV]Life Sciences [q-bio]
Programmed Cell Death 1 Receptor
B7-H1 Antigen
MESH: Decidua
Immune tolerance
MESH: Pregnancy
0302 clinical medicine
Pregnancy
MESH: B7-H1 Antigen
Homeostasis
Innate
Immunology and Allergy
Lymphocytes
Receptor
Hepatitis A Virus Cellular Receptor 2
MESH: Cytokines
Innate lymphoid cell
Decidua
MESH: Programmed Cell Death 1 Receptor
Trophoblasts
MESH: Placental Circulation
3. Good health
Cell biology
medicine.anatomical_structure
MESH: Homeostasis
Cytokines
Female
MESH: Immunity, Innate
Signal transduction
Signal Transduction
Programmed cell death
MESH: Immune Tolerance
T cell
Immunology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
03 medical and health sciences
Immune system
Immune Tolerance
medicine
Humans
Placental Circulation
MESH: Humans
Immunity
Immunity, Innate
MESH: Hepatitis A Virus Cellular Receptor 2
030104 developmental biology
MESH: Lymphocytes
MESH: Female
030215 immunology
Subjects
Details
- ISSN :
- 19330219 and 19353456
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Mucosal Immunology
- Accession number :
- edsair.doi.dedup.....544542d84e8ec426c3279ff349c72459