Back to Search
Start Over
Hadrontherapy Interactions in Molecular and Cellular Biology
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 1, p 133 (2019), International Journal of Molecular Sciences, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩, International Journal of Molecular Sciences, MDPI, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩
- Publication Year :
- 2019
-
Abstract
- CERVOXY COLL; International audience; The resistance of cancer cells to radiotherapy is a major issue in the curative treatment of cancer patients. This resistance can be intrinsic or acquired after irradiation and has various definitions, depending on the endpoint that is chosen in assessing the response to radiation. This phenomenon might be strengthened by the radiosensitivity of surrounding healthy tissues. Sensitive organs near the tumor that is to be treated can be affected by direct irradiation or experience nontargeted reactions, leading to early or late effects that disrupt the quality of life of patients. For several decades, new modalities of irradiation that involve accelerated particles have been available, such as proton therapy and carbon therapy, raising the possibility of specifically targeting the tumor volume. The goal of this review is to examine the up-to-date radiobiological and clinical aspects of hadrontherapy, a discipline that is maturing, with promising applications. We first describe the physical and biological advantages of particles and their application in cancer treatment. The contribution of the microenvironment and surrounding healthy tissues to tumor radioresistance is then discussed, in relation to imaging and accurate visualization of potentially resistant hypoxic areas using dedicated markers, to identify patients and tumors that could benefit from hadrontherapy over conventional irradiation. Finally, we consider combined treatment strategies to improve the particle therapy of radioresistant cancers.
- Subjects :
- Carbon therapy
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Review
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Radioresistance
Neoplasms
hadrontherapy
medicine
Proton Therapy
Humans
cancer
Radiosensitivity
Physical and Theoretical Chemistry
Molecular Biology
Proton therapy
lcsh:QH301-705.5
Spectroscopy
030304 developmental biology
0303 health sciences
Particle therapy
Radiotherapy
business.industry
hypoxia
Organic Chemistry
Cancer
General Medicine
medicine.disease
3. Good health
Computer Science Applications
Radiation therapy
radioresistance
lcsh:Biology (General)
lcsh:QD1-999
particle therapy
030220 oncology & carcinogenesis
Cancer cell
Cancer research
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
business
Subjects
Details
- ISSN :
- 14220067 and 16616596
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....545337e055e28e55974b7fd828cf845e