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Therapeutic Evaluation of Combination Therapy using C-425, Human Native Immunoglobulin Liquid Preparation for i.v. Administration, with Antibiotics in Severe Infections in the Field of Surgery

Authors :
Yoshio MISHIMA
Toshinao INOUE
Hiroshi HAYASAKA
Morio TOTSUKA
Toshiaki EBATA
Ryoichi MOTOKI
Hitoshi INOUE
Yukio ENDO
Shoetsu TAMAKUMA
Jun IMAI
Yasuhiko MORIOKA
Masaru ISHIYAMA
Chiyuki WATANABE
Kozaburo KIMURA
Shigekatsu KURIHARA
Atsushi NAKAZIMA
Kyuya ISHIBIKI
Naoki AIKAWA
Hiroshi TAKAGI
Noboru TAIRA
Kazue OZAWA
Yasuyuki SHIMAHARA
Takesada MORI
Junichi KANBAYASHI
Yoichi SAITO
Hiroyasu NISHIYAMA
Source :
Journal of the Japanese Association for Infectious Diseases. 64:54-64
Publication Year :
1990
Publisher :
The Japanese Association for Infectious Diseases, 1990.

Abstract

In a nationwide study conducted in 11 surgical institutions of C-425, a newly developed human native immunoglobulin liquid preparation for intravenous injection, was combined with conventional antibiotic treatment to investigate the efficacy and safety. A total of 47 patients with severe infections which had not symptomatically responded to 3-day or longer treatment with any antibiotics was included. Doctors in charge judged the efficacy of C-425 to be "excellent" in 3 patients, "good" in 13, "fair" in 15, and "poor" in 4. Thus, a total of 16 patients (45.7%) was judged to have responded to C-425 when the "excellent" and "good" responses were combined. The number responding was 31 (88.6%) when the "fair" cases were also included. Excluding 31 patients who did not meet the Committee's criteria, the Committee judged the efficacy of C-425 in a total of 16 patients; the efficacy was "excellent" in 2 patients, "good" in 4, "fair" in 9, and "poor" in 1. The number of responding patients was 6 (37.5%) of the 16 when the "excellent" and "good" cases were combined, and 15 (93.8%) when the "fair" cases were added. Bacteriological assessment was conducted in a total of 9 patients. Causative bacteria were eradicated in 3 patients, decreased in number in 1, replaced in 2, and persisted in 3. Thus, bacteriological efficacy was observed in 6 of the 9 patients (66.7%). Neither adverse reactions nor drug-related laboratory abnormalities were observed in the 47 patients.

Details

ISSN :
1884569X and 03875911
Volume :
64
Database :
OpenAIRE
Journal :
Journal of the Japanese Association for Infectious Diseases
Accession number :
edsair.doi.dedup.....545c1b7f683815d3b7647c5bb460671d
Full Text :
https://doi.org/10.11150/kansenshogakuzasshi1970.64.54