Back to Search
Start Over
The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors
- Source :
- Molecules, Vol 27, Iss 210, p 210 (2022), Molecules
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- G protein-coupled receptors (GPCRs) represent the largest membrane protein family and a significant target class for therapeutics. Receptors from GPCRs’ largest class, class A, influence virtually every aspect of human physiology. About 45% of the members of this family endogenously bind flexible peptides or peptides segments within larger protein ligands. While many of these peptides have been structurally characterized in their solution state, the few studies of peptides in their receptor-bound state suggest that these peptides interact with a shared set of residues and undergo significant conformational changes. For the purpose of understanding binding dynamics and the development of peptidomimetic drug compounds, further studies should investigate the peptide ligands that are complexed to their cognate receptor.
- Subjects :
- Models, Molecular
Molecular Conformation
Pharmaceutical Science
Organic chemistry
non-canonical amino acids
Review
peptide GPCR
class A GPCR
peptide docking
Ligands
Analytical Chemistry
Receptors, G-Protein-Coupled
Structure-Activity Relationship
QD241-441
Drug Discovery
Humans
Protein Interaction Domains and Motifs
Amino Acid Sequence
Physical and Theoretical Chemistry
Conserved Sequence
Binding Sites
Chemistry (miscellaneous)
ddc:540
Molecular Medicine
Peptides
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 210
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....546554e3f0fe1f512a2dc8d59c619b94