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Negative selection and protection of normal progenitor cells for autografting
Negative selection and protection of normal progenitor cells for autografting
- Source :
- Bone Marrow Transplantation. 22:423-430
- Publication Year :
- 1998
- Publisher :
- Springer Science and Business Media LLC, 1998.
-
Abstract
- Autologous bone marrow transplantation (ABMT) after high-dose chemotherapy is recognized as a curative approach to treating hematologic malignancies and some invasive solid tumors. However, tumor cells present in the bone marrow at the time of harvesting are a potential cause for relapse. Ex vivo marrow purging with very high doses of cytotoxic agents has been introduced in an attempt to remove neoplastic cells contaminating the autograft. The procedure, however, has been limited by its high toxicity to normal bone marrow progenitor cells. In their purging procedures, investigators have used agents such as amifostine, originally developed to protect against the effects of radiation and chemotherapy. In this article, the appropriateness of protecting normal cells with amifostine during various purging procedures will be reviewed.
- Subjects :
- Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Bone Marrow Cells
Transplantation, Autologous
Humans
Medicine
Progenitor cell
Cytotoxicity
Bone Marrow Transplantation
Transplantation
Chemotherapy
business.industry
Bone Marrow Purging
Hematology
Amifostine
Radiation therapy
medicine.anatomical_structure
Toxicity
Cancer research
Female
Bone marrow
business
Ex vivo
medicine.drug
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....54686d84ca92765a8b2d9070a580eb12
- Full Text :
- https://doi.org/10.1038/sj.bmt.1701360