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The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Source :
- Adv Nutr
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Several randomized clinical trials have investigated the effect of dietary advanced glycation end products (AGEs) on metabolic syndrome risk factors in adults. However, the results of these studies were conflicting. Therefore, our aim was to assess the effect of dietary AGEs on metabolic syndrome risk factors. We searched the PubMed-MEDLINE, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases for papers published up to October 2019 that investigated the effect of dietary AGEs on metabolic syndrome risk factors. From the eligible trials, 13 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I(2) statistics and Cochrane Q test. Pooled results from the random-effects model showed a significant reduction for insulin resistance [weighted mean difference (WMD): −1.204; 95% CI: −2.057, −0.358; P = 0.006], fasting insulin (WMD: −5.472 μU/mL; 95% CI: −9.718, −1.234 μU/mL; P = 0.011), total cholesterol (WMD: −5.486 mg/dL; 95% CI: −10.222, −0.747 mg/dL; P = 0.023), and LDL (WMD: −6.263 mg/dL; 95% CI: −11.659, −0.866 mg/dL; P = 0.023) in the low-AGEs groups compared with the high-AGEs groups. There were no changes in the other components of the metabolic syndrome. The results of this review suggest that a diet with a low AGEs content has beneficial effects on insulin resistance, fasting insulin, total cholesterol, and LDL. Moreover, following a diet low in AGEs may be a helpful strategy to decrease the burden of metabolic syndrome risk factors in adults and particularly in patients with diabetes.
- Subjects :
- Adult
Glycation End Products, Advanced
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Medicine (miscellaneous)
030209 endocrinology & metabolism
Review
law.invention
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Randomized controlled trial
law
Glycation
Internal medicine
Diabetes mellitus
Humans
Medicine
Randomized Controlled Trials as Topic
Metabolic Syndrome
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Insulin
Metabolic risk
medicine.disease
Diet
Meta-analysis
Insulin Resistance
Metabolic syndrome
business
Food Science
Subjects
Details
- ISSN :
- 21618313
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Advances in Nutrition
- Accession number :
- edsair.doi.dedup.....5492dccff447659a93ac33db8807b9b1