Back to Search
Start Over
Motor milestone assessment of infants with spinal muscular atrophy using the hammersmith infant neurological Exam—Part 2: Experience from a nusinersen clinical study
- Source :
- Muscle & Nerve. 57:142-146
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- INTRODUCTION: We examined the feasibility of assessing motor milestone performance of infants with spinal muscular atrophy (SMA) using the Hammersmith Infant Neurological Exam - Part 2 (HINE-2) in a Phase 2 study of nusinersen. METHODS: Nineteen SMA infants were assessed using the HINE-2 at baseline (≤ 7 months of age), and periodically up to 39 months of age. We evaluated whether the HINE-2 was feasible, reliable, and sensitive to change. RESULTS: Motor milestone assessments in SMA infants were feasible using the HINE-2. Baseline test-retest reliability was excellent (R= 0.987; p
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Pediatrics
Physiology
Developmental Disabilities
Movement
Oligonucleotides
Spinal Muscular Atrophies of Childhood
Sensitivity and Specificity
Clinical study
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Physiology (medical)
Milestone (project management)
medicine
Humans
Neurologic Examination
Observer Variation
business.industry
Outcome measures
Infant
Reproducibility of Results
Neurological exam
Spinal muscular atrophy
Reference Standards
SMA
medicine.disease
Clinical trial
030104 developmental biology
Child, Preschool
Disease Progression
Physical therapy
Female
Nusinersen
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10974598 and 0148639X
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Muscle & Nerve
- Accession number :
- edsair.doi.dedup.....549d7805f2c652a848ce6d85668c8cc3
- Full Text :
- https://doi.org/10.1002/mus.25705