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Impact of the Severity of Alzheimer’s Disease on the Quality of Life, Activities of Daily Living, and Caregiving Costs for Institutionalized Patients on Anti-Alzheimer Medications in Japan
- Source :
- Journal of Alzheimer's Disease
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Alzheimer’s disease (AD) increases societal costs and decreases the activities of daily living (ADL) and quality of life (QoL) of the affected individuals. Objective: We assess the impact of AD severity on ADL, QoL, and caregiving costs in Japanese facilities for the elderly. Methods: Patients with AD in facilities for the elderly were included (47 facilities, N = 3,461). The QoL, ADL, and disease severity of patients were assessed using Barthel Index (BI), EuroQoL-5D-5L (EQ-5D-5L), and Mini-Mental State Examination (MMSE), respectively. Annual caregiving costs were estimated using patients’ claims data. The patients were subcategorized into the following three groups according to the MMSE score: mild (21≤MMSE≤30), moderate (11≤MMSE≤20), and severe (0≤MMSE≤10). Changes among the three groups were evaluated using the Jonckheere-Terpstra test. Results: Four hundred and one participants were on anti-AD medicines, of whom 287 (age: 86.1±6.4 years, 76.7% women) in the mild (n = 53, 84.0±6.9 years, 71.7%), moderate (n = 118, 86.6±5.9 years, 76.3%), and severe (n = 116, 86.6±6.5 years, 79.3%) groups completed the study questionnaires. The mean BI and EQ-5D-5L scores for each group were 83.6, 65.1, and 32.8 and 0.801, 0.662, and 0.436, respectively. The mean annual caregiving costs were 2.111, 2.470, and 2.809 million JPY, respectively. As AD worsened, the BI and EQ-5D-5L scores decreased and annual caregiving costs increased significantly. Conclusion: AD severity has an impact on QoL, ADL, and caregiving costs.
- Subjects :
- Male
Gerontology
Activities of daily living
Barthel index
cost of illness
Disease
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Japan
Quality of life
Disease severity
Alzheimer Disease
Surveys and Questionnaires
Humans
Medicine
030212 general & internal medicine
Aged
Aged, 80 and over
Anti alzheimer
business.industry
General Neuroscience
Institutionalization
Health Care Costs
General Medicine
Psychiatry and Mental health
Clinical Psychology
Mmse score
Caregivers
quality of life
Female
observational study
Observational study
Geriatrics and Gerontology
business
Alzheimer’s disease
human activities
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....54aa05e3b366916ce311a56d6285b2cf
- Full Text :
- https://doi.org/10.3233/jad-201514