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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
- Source :
- Diagnostics, Vol 10, Iss 922, p 922 (2020), Diagnostics
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia.
- Subjects :
- medicine.medical_specialty
Pain tolerance
Clinical Biochemistry
Psychological intervention
Review
cortisol
03 medical and health sciences
0302 clinical medicine
Fibromyalgia
medicine
In patient
030203 arthritis & rheumatology
lcsh:R5-920
treatment
business.industry
Data synthesis
Chronic pain
medicine.disease
meta-analysis
Meta-analysis
Physical therapy
Observational study
fibromyalgia
business
chronic pain
lcsh:Medicine (General)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 10
- Issue :
- 922
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....54cb143fccb6bd80eecd624d84748c4a