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The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- To investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those of pericentral and other types. In the subgroup analysis, 41 and 21 eyes of the typical and pericentral types were studied, respectively. The correlation between the estimated preserved photoreceptor area and all ffERG amplitude parameters were significant in the typical type, but not in pericentral type. Old age, decreased intact ellipsoid zone length, typical type, and thin central retinal thickness were negatively correlated with BCVA. Typical type RP developed more extensive degeneration and poorer BCVA compared to others. Strong structure–function correlation was found in typical type while not in pericentral type. OCT may be a useful tool for monitoring RP status in typical type, providing useful parameters for the prediction of BCVA.
- Subjects :
- Adult
Male
medicine.medical_specialty
Visual acuity
Adolescent
genetic structures
Science
Biology
Predictive markers
Article
Structure function correlation
Structure-Activity Relationship
Young Adult
chemistry.chemical_compound
Medical research
Optical coherence tomography
Ophthalmology
Retinitis pigmentosa
Linear regression
Electroretinography
medicine
Humans
Macula Lutea
Full field erg
Aged
Multidisciplinary
medicine.diagnostic_test
Retinal
Middle Aged
medicine.disease
eye diseases
chemistry
Multivariate Analysis
Linear Models
Medicine
Female
sense organs
medicine.symptom
Retinitis Pigmentosa
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....54f544317f2aac26d3f63e1ee7ce0d48