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Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year
- Source :
- The Journal of Allergy and Clinical Immunology
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown. Methods We randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples. Results Bacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus . In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD. Conclusions This study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.
- Subjects :
- Male
0301 basic medicine
Longitudinal birth cohort
microbiome
Disease
Filaggrin Proteins
medicine.disease_cause
16S sequencing
030207 dermatology & venereal diseases
0302 clinical medicine
Intermediate Filament Proteins
Risk Factors
RNA, Ribosomal, 16S
Immunology and Allergy
OTU, Operational taxonomic unit
Skin
Atopic Dermatitis and Skin Disease
FLG, Filaggrin
atopic dermatitis
Nt, Nasal tip
Microbiota
Atopic dermatitis
Pf, Popliteal fossa
3. Good health
RNA, Bacterial
Staphylococcus aureus
Child, Preschool
AD, Atopic dermatitis
Female
Filaggrin
skin
Immunology
AMOVA, Analysis of molecular variance
Biology
Lower risk
Dermatitis, Atopic
03 medical and health sciences
medicine
Humans
Skin immunity
Microbiome
Af, Antecubital fossa
Bacteria
Infant
longitudinal birth cohort
medicine.disease
030104 developmental biology
BASELINE, Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints
Dysbiosis
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 139
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....5504d2b828c4b3f35c3efaae878e9401
- Full Text :
- https://doi.org/10.1016/j.jaci.2016.07.029