Effect of Eplerenone on Diastolic Function in Women Receiving Anthracycline-Based Chemotherapy for Breast Cancer

Anthracycline agents are commonly used in early breast cancer but are associated with dose-related cardiotoxicity. Diastolic dysfunction may be more common and occur earlier than systolic dysfunction ([1][1],[2][2]). Eplerenone is an oral mineralocorticoid antagonist (MRA); these agents prevent