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ASSOCIATION BETWEEN ADIPOQ SNPS WITH PLASMA ADIPONECTIN AND GLUCOSE HOMEOSTASIS AND ADIPOSITY PHENOTYPES IN THE IRAS FAMILY STUDY
- Publication Year :
- 2012
-
Abstract
- Context Adiponectin is an adipocytokine associated with a variety of metabolic traits. These associations in human studies, in conjunction with functional studies in model systems, have implicated adiponectin in multiple metabolic processes. Objective We hypothesize that genetic variants associated with plasma adiponectin would also be associated with glucose homeostasis and adiposity phenotypes. Design and Setting The Insulin Resistance Atherosclerosis Family Study was designed to identify the genetic and environmental basis of insulin resistance and adiposity in the Hispanic- ( n =1,424) and African-American ( n =604) population. Main Outcome Measures High quality metabolic phenotypes, e.g. insulin sensitivity (S I ), acute insulin response (AIR), disposition index (DI), fasting glucose, body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and waist circumference, were explored. Results Based on association analysis of more than 40 genetic polymorphisms in the adiponectin gene ( ADIPOQ ), we found no consistent association of ADIPOQ variants with plasma adiponectin levels and adiposity phenotypes. However, there were two promoter variants, rs17300539 and rs822387, associated with plasma adiponectin levels ( P =0.0079 and 0.021, respectively) in the Hispanic-American cohort that were also associated with S I ( P =0.0067 and 0.013, respectively). In contrast, there was only a single promoter SNP, rs17300539, associated with plasma adiponectin levels ( P =0.0018) and fasting glucose ( P =0.042) in the African-American cohort. Strikingly, high impact coding variants did not show evidence of association. Conclusions The lack of consistent patterns of association between variants, adiponectin levels, glucose homeostasis, and adiposity phenotypes suggests a reassessment of the influence of adiponectin in these pathways.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Adipose tissue
Context (language use)
Biology
Biochemistry
Polymorphism, Single Nucleotide
Article
Endocrinology
Insulin resistance
Internal medicine
Genetics
medicine
Glucose homeostasis
Homeostasis
Humans
education
Molecular Biology
Alleles
Genetic Association Studies
Genetic association
Adiposity
education.field_of_study
Adiponectin
Hispanic or Latino
Middle Aged
medicine.disease
Black or African American
Glucose
Phenotype
Female
Body mass index
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5521742561c78c58e5e7c8c101a862f7