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Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants

Authors :
Bin Tu
Huiyuan Wang
Xinran An
Jingkun Qu
Qianqian Li
Yanrong Gao
Mingjie Shi
Hong Qiu
Yongzhuo Huang
Source :
Acta Pharmaceutica Sinica B. 12:3187-3194
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

The heparin polysaccharide nanoparticles block the interaction between heparan sulfate/S protein and inhibit the infection of both wild-type SARS-CoV-2 pseudovirus and the mutated strains through pulmonary delivery.Image 1.

Subjects

Subjects :
General Pharmacology, Toxicology and Pharmaceutics

Details

ISSN :
22113835
Volume :
12
Database :
OpenAIRE
Journal :
Acta Pharmaceutica Sinica B
Accession number :
edsair.doi.dedup.....5525f781935cd57628f3afc5b5a5315d
Full Text :
https://doi.org/10.1016/j.apsb.2022.01.019
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