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Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway
- Source :
- The American Journal of Chinese Medicine. 49:1215-1233
- Publication Year :
- 2021
- Publisher :
- World Scientific Pub Co Pte Ltd, 2021.
-
Abstract
- Although ginseng (Panax ginseng C.A. Meyer) has received extensive attention in the treatment and prevention of type 2 diabetes mellitus (T2DM) in the past few decades, there are few studies on the complications of T2DM. At present, obesity-linked diabetic nephropathy (DN) has become the most prevailing element of the end-stage renal failure in the world. The aim of this work is to evaluate the ameliorative effects of ginsenoside Rh1 (G-Rh1) on DN induced by high fat diet plus streptozotocin (HFD/STZ) through some potential and combined mechanisms of action. The results showed that G-Rh1 treatment at 5 and 10 mg/kg for 8 weeks exerted excellent effects in controlling fasting blood glucose (FBG), improving glucose tolerance, and increasing insulin level. In addition, G-Rh1 effectively prevents the excessive production of advanced glycation end products (AGEs), a diabetic nephropathy marker, in HFD/STZ induced DN mice. Meanwhile, oxidation indicators including SOD, GSH, and MDA were improved by G-Rh1 treatment to varying degrees. It is worth noting that G-Rh1 not only inhibits the secretion of Nox1 and Nox4 in kidney tissues, but also has an inhibitory effect on inflammatory factors and NF-[Formula: see text]B signaling pathway. Importantly, further in-depth research on molecular mechanisms provides vital evidence that the ameliorative effect of G-Rh1 on DN is related to the inhibition of apoptosis and the AMPK/PI3K/Akt signaling pathway. In summary, G-Rh1 may be of great value in improving the treatment of DN although more experimental data is needed.
- Subjects :
- 0301 basic medicine
Ginsenosides
Apoptosis
AMP-Activated Protein Kinases
Pharmacology
Diet, High-Fat
Streptozocin
Diabetes Mellitus, Experimental
Diabetic nephropathy
Mice
Phosphatidylinositol 3-Kinases
03 medical and health sciences
Ginseng
0302 clinical medicine
Glycation
medicine
Animals
Diabetic Nephropathies
Protein kinase B
PI3K/AKT/mTOR pathway
Inflammation
Molecular Structure
Akt/PKB signaling pathway
business.industry
AMPK
General Medicine
medicine.disease
Streptozotocin
030104 developmental biology
Complementary and alternative medicine
030220 oncology & carcinogenesis
Inflammation Mediators
business
Proto-Oncogene Proteins c-akt
medicine.drug
Subjects
Details
- ISSN :
- 17936853 and 0192415X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- The American Journal of Chinese Medicine
- Accession number :
- edsair.doi.dedup.....553afd55d34998877a1e79402ad30d3a