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Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Although several studies have confirmed the clinical significance of the systemic inflammation markers in hepatocellular carcinoma (HCC), evaluating the clinical significance of each blood cell remains to be conducted. We aimed to evaluate the clinical importance of absolute counts of blood cells in the overall survival (OS) of patients with newly diagnosed HCC. We recruited patient cohorts from the prospective registry of newly diagnosed and previously untreated HCC at Samsung Medical Center, which included a training set of 6619 patients (2005–2013) and a validation set of 2084 patients (2014–2016). More than three-quarters of all patients had hepatitis B virus (HBV)-related HCC in both training and validation sets. The optimal cutoff values of the absolute counts of neutrophils, lymphocytes, monocytes, and platelets were 3917, 488, 1379, and 22,100, respectively, which correlated significantly with OS. The absolute blood cell counts categorized by each optimal cutoff value significantly correlated with liver function status determined by Child–Pugh class/albumin-bilirubin (ALBI) grade and the HCC burden determined by several staging systems/portal vein tumor thrombosis. Although the prognostic model based on these blood cells (ABC model) showed a lower prognostic ability than the Japan Integrated Staging or ALBI-T staging systems, it provided significant discrimination of survival in the subgroups of ALBI-T and showed the highest prognostic ability in the present study in the training and validation sets. Absolute counts of blood cells are independently associated with OS, though it is also significantly associated with liver function and tumor burden in newly diagnosed HCC.
- Subjects :
- Male
0301 basic medicine
Systemic inflammation
medicine.disease_cause
Gastroenterology
Cohort Studies
Blood cell
0302 clinical medicine
Registries
Cancer
Aged, 80 and over
Multidisciplinary
Liver Neoplasms
Middle Aged
Prognosis
Thrombosis
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Medicine
Female
medicine.symptom
Adult
medicine.medical_specialty
Carcinoma, Hepatocellular
Adolescent
Science
Article
Young Adult
03 medical and health sciences
Internal medicine
Republic of Korea
medicine
Humans
Clinical significance
Lymphocyte Count
Aged
Neoplasm Staging
Hepatitis B virus
Platelet Count
business.industry
Albumin
medicine.disease
030104 developmental biology
Liver function
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....5540677cd019488a7606c53645c97b1f