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Prediction of subtle left ventricular systolic dysfunction in homozygous and heterozygous familial hypercholesterolemia: Genetic analyses and speckle tracking echocardiography study
- Source :
- Echocardiography. 35:1289-1299
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND AND AIMS Few studies have shown the direct effect of familial hypercholesterolemia (FH) on myocardial systolic function. Studies focused on heterozygote FH patients but not homozygote ones, and they did not perform genetic analyses. We aimed to evaluate all types of patients with FH using the potentially more sensitive speckle tracking echocardiography (STE) technique to identify early left ventricular (LV) dysfunction. METHODS Genetic analyses of patients with FH were conducted for LDL-receptor, PCSK9, and ApoB100. Nine homozygote, two compound heterozygote, and 82 heterozygote FH patients and 85 healthy subjects were prospectively studied. Longitudinal and circumferential strain measurements and conventional echocardiography findings were obtained. RESULTS LV ejection fractions were similar for all (homozygote, heterozygote, and control) groups. The LV average longitudinal strain (aLS) and average circumferential strain (aCS) levels were significantly reduced in the homozygote and heterozygote groups when compared with the controls (for aLS, P = .008 (
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Apolipoprotein B
Heart Ventricles
Speckle tracking echocardiography
Familial hypercholesterolemia
030204 cardiovascular system & hematology
Compound heterozygosity
Hyperlipoproteinemia Type II
Ventricular Dysfunction, Left
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Ejection fraction
biology
business.industry
PCSK9
Hypertrophic cardiomyopathy
Reproducibility of Results
Heterozygote advantage
medicine.disease
030104 developmental biology
Receptors, LDL
Echocardiography
Apolipoprotein B-100
Cardiology
biology.protein
Female
Proprotein Convertase 9
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 07422822
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Echocardiography
- Accession number :
- edsair.doi.dedup.....55421511991027f1ea123b233e9db6e7