DNA fragmentation is a feature of cystic fibrosis epithelial cells: a disease with inappropriate apoptosis?

Authors :: Valeria Raia
Marco Londei
Luigi Maiuri
Giorgio de Ritis
S. Coletta
Salvatore Auricchio
Giulio De Marco
Maiuri, L
Raia, Valeria
DE MARCO, G
Coletta, S
DE RITIS, G
Londei, M
Auricchio, S.
Publication Year :: 1997
Publisher :: Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598, 1997.
Abstract: Cystic fibrosis (CF) is a single-gene disease caused by mutations in the CFTR gene, which result in disrupted chloride secretions with inspissated mucous secretions by exocrine glands. Nick-end labelling was used to assess DNA fragmentation in 14 CF and 24 control duodenal samples, and in two CF and two control lung tissues. In CF small intestine median 46% (range: 30–82) villus enterocytes show DNA fragmentation (vs. 3% (range: 1–7) in controls P

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