Back to Search
Start Over
Disconnectome of the migraine brain: a 'connectopathy' model
- Source :
- The Journal of Headache and Pain, The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Milan, 2021.
-
Abstract
- Background In the past decades a plethora of studies has been conducted to explore resting-state functional connectivity (RS-FC) of the brain networks in migraine with conflicting results probably due to the variability and susceptibility of signal fluctuations across the course of RS-FC scan. On the other hand, the structural substrates enabling the functional communications among the brain connectome, characterized by higher stability and reproducibility, have not been widely investigated in migraine by means of graph analysis approach. We hypothesize a rearrangement of the brain connectome with an increase of both strength and density of connections between cortical areas specifically involved in pain perception, processing and modulation in migraine patients. Moreover, such connectome rearrangement, inducing an imbalance between the competing parameters of network efficiency and segregation, may underpin a mismatch between energy resources and demand representing the neuronal correlate of the energetically dysfunctional migraine brain. Methods We investigated, using diffusion-weighted MRI imaging tractography-based graph analysis, the graph-topological indices of the brain “connectome”, a set of grey matter regions (nodes) structurally connected by white matter paths (edges) in 94 patients with migraine without aura compared to 91 healthy controls. Results We observed in migraine patients compared to healthy controls: i) higher local and global network efficiency (p p p Conclusion The imbalance between the need of investing resources to promote network efficiency and the need of minimizing the metabolic cost of wiring probably represents the mechanism underlying migraine patients’ susceptibility to triggers. Such changes in connectome topography suggest an intriguing pathophysiological model of migraine as brain “connectopathy”.
- Subjects :
- Migraine Disorders
Reproducibility of Result
Graph analysis
Grey matter
White matter
Connectome
Medicine
Humans
Gray Matter
Migraine
Advanced neuroimaging
business.industry
Brain
Reproducibility of Results
Cognition
Inferior parietal lobule
General Medicine
medicine.disease
Brain network
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Graph analysi
Posterior cingulate
Neurology (clinical)
business
Neuroscience
Human
Tractography
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 11292377 and 11292369
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of Headache and Pain
- Accession number :
- edsair.doi.dedup.....559d43b2bc0ff025e0d59a53e4031dc5