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The antimalarial activity of indole alkaloids and hybrids
- Source :
- Archiv der Pharmazie. 353:2000131
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Malaria, caused by the genus Plasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains. Indole derivatives, which possess broad-spectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug-sensitive and drug-resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents. This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade.
- Subjects :
- Plasmodium
Population
Drug Resistance
Pharmaceutical Science
Biology
01 natural sciences
World health
Host-Parasite Interactions
Indole Alkaloids
Antimalarials
Structure-Activity Relationship
Drug Discovery
medicine
Animals
Humans
Antimalarial Agent
education
Indole test
education.field_of_study
Molecular Structure
Traditional medicine
010405 organic chemistry
medicine.disease
Malaria
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Infectious disease (medical specialty)
Subjects
Details
- ISSN :
- 15214184 and 03656233
- Volume :
- 353
- Database :
- OpenAIRE
- Journal :
- Archiv der Pharmazie
- Accession number :
- edsair.doi.dedup.....55a2fc9457715d24bc367ac1d94dabaf