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CMTM3 inhibits cell growth and migration and predicts favorable survival in oral squamous cell carcinoma
- Source :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(10)
- Publication Year :
- 2015
-
Abstract
- Downregulation of CKLF-like MARVEL transmembrane domain-containing member 3 (CMTM3) has been reported in a number of human tumors. However, the role of CMTM3 in oral squamous cell carcinoma (OSCC) remains largely unknown. In this study, we showed that the expression of CMTM3 was significantly reduced in OSCC cell lines and primary tumor specimens (P
- Subjects :
- Oncology
Male
medicine.medical_specialty
Tumor suppressor gene
Blotting, Western
Mice, Nude
Apoptosis
Real-Time Polymerase Chain Reaction
Immunoenzyme Techniques
Mice
Downregulation and upregulation
In vivo
Cell Movement
Internal medicine
Biomarkers, Tumor
Tumor Cells, Cultured
Medicine
Animals
Humans
RNA, Messenger
Promoter Regions, Genetic
Cell Proliferation
Neoplasm Staging
Mice, Inbred BALB C
MARVEL Domain-Containing Proteins
business.industry
Cell growth
Reverse Transcriptase Polymerase Chain Reaction
General Medicine
DNA Methylation
Middle Aged
medicine.disease
Prognosis
Primary tumor
Xenograft Model Antitumor Assays
Gene Expression Regulation, Neoplastic
stomatognathic diseases
Cell culture
Lymphatic Metastasis
DNA methylation
Carcinoma, Squamous Cell
T-stage
Female
Mouth Neoplasms
Chemokines
Neoplasm Grading
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 14230380
- Volume :
- 36
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....55c36d388c6436521ec1b35cfd7d723e