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Megaloblastic anemia-related iron overload and erythroid regulators: a case report
- Source :
- Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021), Journal of Medical Case Reports
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background In ineffective erythropoiesis, hepcidin synthesis is suppressed by erythroid regulators, namely erythroferrone and growth differentiation factor-15. For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload. Case presentation An 81-year-old Caucasian male was admitted for fatigue. He had type-2 diabetes previously treated with metformin, ischemic cardiac insufficiency, and stage-3 chronic kidney disease. Vitiligo was observed on both hands. Biological tests revealed normocytic non-regenerative anemia associated with hemolysis, thrombocytopenia, and elevated sideremia, ferritin, and transferrin saturation levels. Megaloblastic anemia was confirmed with undetectable blood vitamin B12 and typical cytological findings like hyper-segmented neutrophils in blood and megaloblasts in bone marrow. The patient received vitamin B12 supplementation. At 3 months, biological parameters reached normal values. Hepcidin kinetics from diagnosis to 3 months inversely correlated with those of erythroferrone and growth differentiation factor-15. Conclusions This case suggests that iron-overload mechanisms of dyserythropoietic anemias may apply to megaloblastic anemias.
- Subjects :
- Ineffective erythropoiesis
Male
Anemia, Megaloblastic
Anemia
Iron
Physiology
medicine.disease_cause
Hepcidin
hemic and lymphatic diseases
Case report
Medicine
Humans
Iron overload
Erythropoiesis
Vitamin B12
Megaloblastic anemia
Aged, 80 and over
biology
business.industry
General Medicine
Erythroferrone
medicine.disease
Ferritin
GDF15
biology.protein
business
Subjects
Details
- Language :
- English
- ISSN :
- 17521947
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Case Reports
- Accession number :
- edsair.doi.dedup.....55cf8f4ca04caaed5f06e300800f1e95