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The Cinderella Effect: Searching for the Best Fit between Mouse Models and Human Diseases

Authors :
Paul N. Schofield
Derry C. Roopenian
Edison T. Liu
John P. Sundberg
Source :
Journal of Investigative Dermatology. 133(11):2509-2513
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

A recent publication questions the suitability of mice as a model for the human inflammatory response and has fueled the continuing debate about the suitability of mice as models for human disease. We discuss recent advances in disease modeling using mice, and the genetic factors that need to be considered when trying to recapitulate aspects of human disease. Failure to appreciate the important differences between human and mouse biology and genetics underlying attempts to generate faithful models frequently leads to poor outcomes. Closely coordinated human and model organism studies are essential to provide traction for translational research.

Details

ISSN :
0022202X
Volume :
133
Issue :
11
Database :
OpenAIRE
Journal :
Journal of Investigative Dermatology
Accession number :
edsair.doi.dedup.....55d9ebbdedbc8b5606b6297e2679d950
Full Text :
https://doi.org/10.1038/jid.2013.238