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The Cinderella Effect: Searching for the Best Fit between Mouse Models and Human Diseases
- Source :
- Journal of Investigative Dermatology. 133(11):2509-2513
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- A recent publication questions the suitability of mice as a model for the human inflammatory response and has fueled the continuing debate about the suitability of mice as models for human disease. We discuss recent advances in disease modeling using mice, and the genetic factors that need to be considered when trying to recapitulate aspects of human disease. Failure to appreciate the important differences between human and mouse biology and genetics underlying attempts to generate faithful models frequently leads to poor outcomes. Closely coordinated human and model organism studies are essential to provide traction for translational research.
- Subjects :
- Cinderella effect
ved/biology
Inflammatory response
ved/biology.organism_classification_rank.species
Translational research
Computational biology
Disease
Cell Biology
Dermatology
Biology
Skin Diseases
Biochemistry
Mice, Inbred C57BL
Translational Research, Biomedical
Disease Models, Animal
Mice
Human disease
Species Specificity
Immunology
Animals
Humans
Model organism
Molecular Biology
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 133
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....55d9ebbdedbc8b5606b6297e2679d950
- Full Text :
- https://doi.org/10.1038/jid.2013.238