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Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse
- Source :
- Frontiers in Neuroanatomy, Vol 12 (2018), Frontiers in Neuroanatomy
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved in detecting salient changes in the external environment. The anterior cingulate cortex (ACC) and the anterior insular (aINS) are the two major participants in the salience network of human brain regions that activate in response to salient stimuli. While bidirectional connections between the ACC and the claustrum exist from mouse to non-human primate, the aINS connectivity with claustrum remains unclear, particularly in mouse. Here, we explored structural connections of the aINS with the claustrum and ACC through adeno-associated virus neuronal tract tracer injections into the ACC and aINS of the mouse. We detected sparse projections from the claustrum to the aINS and diffuse projections from the aINS to the borders of the claustrum were observed in some cases. In contrast, the insular cortex and endopiriform nucleus surrounding the claustrum had rich interconnectivity with aINS. Additionally, we observed a modest interconnectivity between ACC and the aINS. These data support the idea that claustrum neuron responses to salient stimuli may be driven by the ACC rather than the aINS.
- Subjects :
- 0301 basic medicine
striatum
Neuroscience (miscellaneous)
Striatum
endopiriform
Biology
retrograde
Insular cortex
behavioral disciplines and activities
lcsh:RC321-571
lcsh:QM1-695
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
medicine
circuitry
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Anterior cingulate cortex
Original Research
Anterior insula
anterograde
food and beverages
Human brain
lcsh:Human anatomy
Claustrum
030104 developmental biology
medicine.anatomical_structure
nervous system
Neuron
salience network
Anatomy
Nucleus
Neuroscience
030217 neurology & neurosurgery
psychological phenomena and processes
Subjects
Details
- Language :
- English
- ISSN :
- 16625129
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neuroanatomy
- Accession number :
- edsair.doi.dedup.....55e53dc3eb5251562ab4fa53bbf381d4