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Antimicrobial, cytotoxic and antioxidative evaluation of natural deep eutectic solvents
Antimicrobial, cytotoxic and antioxidative evaluation of natural deep eutectic solvents
- Publication Year :
- 2018
-
Abstract
- Natural deep eutectic solvents (NADES) are a new generation of green solvents. They are mixtures of two or three compounds such as choline chloride as a cationic salt and alcohols, acids, amides, amines or sugars as hydrogen-bond donors. Although the majority of NADES’ components are of natural origin and therefore NADES are often presumed to be non- toxic, the evaluation of their toxicity and biodegradability must accompany the research on their synthesis and application. Therefore, the aim of this work was to investigate the effect of ten synthesised NADES towards bacteria (i.e., Escherichia coli, Proteus mirabilis, Salmonella typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus), yeast (i.e., Candida albicans) and human cell lines (i.e., HeLa, MCF-7 and HEK293T). In addition, oxygen radical absorbance capacity (ORAC) method was used to determine the antioxidative activity of the tested NADES. Differences in toxicity response between microorganisms and cell lines were observed, and only NADES that contained organic acid showed toxicity towards the test systems. Furthermore, the NADES containing compounds that possess antioxidative activity also showed antioxidative activity. However, research whose primary purpose is the synthesis and application of NADES must be followed by an evaluation of their biological properties (e.g., antimicrobial activity, toxicity towards animal cells and antioxidative or other biological activity) to find the solvent with the best profile for wider industrial applications.
- Subjects :
- Oxygen radical absorbance capacity
Health, Toxicology and Mutagenesis
02 engineering and technology
Microbial Sensitivity Tests
01 natural sciences
Antioxidants
chemistry.chemical_compound
Anti-Infective Agents
Environmental Chemistry
Animals
Humans
Food science
Cell Proliferation
chemistry.chemical_classification
biology
010405 organic chemistry
Biological activity
Green Chemistry Technology
Hydrogen Bonding
General Medicine
Biodegradation
021001 nanoscience & nanotechnology
biology.organism_classification
Antimicrobial
Pollution
Yeast
0104 chemical sciences
Anti-Bacterial Agents
antimicrobial activity, antioxidative activity, cytotoxicity, natural deep eutectic solvents, ORAC
HEK293 Cells
chemistry
MCF-7 Cells
Solvents
0210 nano-technology
Bacteria
Choline chloride
Organic acid
HeLa Cells
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....55e9d603693f15b71e8f81a759948078
- Full Text :
- https://doi.org/10.1007/s11356-018-1669-z