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Plasma Procalcitonin Is an Independent Predictor of Graft Failure Late After Renal Transplantation

Authors :
Leendert H. Oterdoom
Jaap J. Homan van der Heide
Reinold O. B. Gans
Jan P. Schouten
Rutger M. van Ree
Aiko P. J. de Vries
Marc A. Seelen
Stephan J. L. Bakker
Willem J. van Son
Gerjan Navis
Ron T. Gansevoort
Joachim Struck
University of Groningen
Cardiovascular Centre (CVC)
Groningen Institute for Organ Transplantation (GIOT)
Lifestyle Medicine (LM)
Groningen Kidney Center (GKC)
Vascular Ageing Programme (VAP)
Other departments
Source :
Transplantation, 88(2), 279-287. LIPPINCOTT WILLIAMS & WILKINS, Transplantation, 88(2), 279-287. Lippincott Williams and Wilkins
Publication Year :
2009
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2009.

Abstract

Chronic low-grade inflammation is involved in chronic transplant dysfunction after renal transplantation. Procalcitonin (PCT), known to reflect microbial inflammation, may also reflect ongoing noninfectious chronic low-grade inflammation in organ parenchyma, including transplanted kidneys. We aimed to compare predictive performance of plasma PCT for development of graft failure in renal transplant recipients (RTR) with that of high-sensitivity C-reactive protein (hsCRP), an established marker of systemic chronic low-grade inflammation. We included 575 RTR with functioning grafts for more than or equal to 1 year at a median (interquartile range) time of 6.1 (2.9-11.7) years posttransplant. PCT was determined using an ultrasensitive immunoluminometric assay and hsCRP using high-sensitivity enzyme-linked immunosorbent assay. Median (interquartile range) plasma PCT and hsCRP concentrations were 0.023 (0.017-0.036) ng/mL and 2.1 (0.8-4.9) mg/L, respectively. After a median (interquartile range) of 5.2 (4.5-5.7) years of follow-up, incidence of graft failure was 0.5%, 2.6%, and 18.5% according to increasing PCT tertiles (P

Details

ISSN :
00411337
Volume :
88
Database :
OpenAIRE
Journal :
Transplantation
Accession number :
edsair.doi.dedup.....55f081c697a5a3a5ca1f6351a233ec10
Full Text :
https://doi.org/10.1097/tp.0b013e3181ac9ea0