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Gestational thrombocytopenia and pregnancy-induced antithrombin deficiency: progenitors to the development of the HELLP syndrome and acute fatty liver of pregnancy
Gestational thrombocytopenia and pregnancy-induced antithrombin deficiency: progenitors to the development of the HELLP syndrome and acute fatty liver of pregnancy
- Source :
- Seminars in thrombosis and hemostasis. 28(6)
- Publication Year :
- 2003
-
Abstract
- The syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) and of acute fatty liver of pregnancy (AFLP) do not have an abrupt onset. Thrombocytopenia or reduced antithrombin activity, or both, seen at presentation do not result from these complications. There are a small number of pregnant women who exhibit a gradual antenatal decline in platelet counts or antithrombin activity, or both, irrespective of the presence or absence of preeclampsia. Those who develop a profound decrease in either platelet counts or antithrombin activity are at an increased risk for developing perinatal aspartate aminotransferase (AST) elevation. Thrombocytopenia or reduced antithrombin activity, or both, precede the onset of these diseases. Therefore, monitoring of platelet counts and antithrombin activity during pregnancy is clinically useful for identifying women at an increased risk of the HELLP syndrome and AFLP. Because women with twin pregnancies are likely to exhibit a decrease in platelet counts or antithrombin activity, or both, compared with women with singleton pregnancies, HELLP syndrome and AFLP are more likely to occur in women with twin pregnancies.
- Subjects :
- medicine.medical_specialty
HELLP Syndrome
Gestational thrombocytopenia
HELLP syndrome
Physiology
Antithrombins
Preeclampsia
Acute fatty liver of pregnancy
Pregnancy
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Aspartate Aminotransferases
business.industry
Antithrombin
Fatty liver
Pregnancy Complications, Hematologic
Hematology
medicine.disease
Thrombocytopenia
Fatty Liver
Endocrinology
Acute Disease
Gestation
Female
Pregnancy, Multiple
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 00946176
- Volume :
- 28
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Seminars in thrombosis and hemostasis
- Accession number :
- edsair.doi.dedup.....55f24c13d0ce1ebe5b739f1e803f916c