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Biotransformation of Eugenol to Dehydroeugenol Catalyzed by Brassica juncea Peroxidase and its Cytotoxicity Activities
- Source :
- Procedia Chemistry. :265-271
- Publisher :
- Published by Elsevier B.V.
-
Abstract
- A crude peroxidase biocatalyst extracted from sawi hijau ( Brassica juncea ) was used to produce dimerization phenolic synthesized from eugenol. The result from MS and NMR analysis showed that the reaction between eugenol substrate and H 2 O 2 with crude extract enzyme produced a new chemical compound. The chemical structure of new compound showed coupled result in ortho-ortho position with C-C coupled derivative, dehydrodieugenol. It was obtained as brownish white crystal needles with yield 10%. This compound displayed higher cytotoxicity effect on T47D breast cancer cell compared to the eugenol monomer.
- Subjects :
- Dehydioeugenol
Chemistry(all)
biology
Chemical structure
Brassica
Substrate (chemistry)
Oxidative coupling
General Medicine
biology.organism_classification
Eugenol
chemistry.chemical_compound
chemistry
Biotransformation
Chemical Engineering(all)
biology.protein
Organic chemistry
Cytotoxicity
Dimerization
Derivative (chemistry)
Peroxidase
Subjects
Details
- Language :
- English
- ISSN :
- 18766196
- Database :
- OpenAIRE
- Journal :
- Procedia Chemistry
- Accession number :
- edsair.doi.dedup.....5610e4c6f353f2bfd5cb5a50c5acd185
- Full Text :
- https://doi.org/10.1016/j.proche.2015.12.049