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Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder
- Source :
- Journal of Clinical Psychopharmacology. 36:27-31
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRI/SNRI) are commonly used for treating major depression. Regretfully, significant heterogeneity exists regarding the benefits of SSRI/SNRI in individual cases. We previously reported that a polymorphism located in the serotonin transporter linked promoter region (5-HTT LPR) is associated with an interindividual difference in SSRI treatment efficacy. However, this explains only a small part of the variation of this complex phenotype. Other 5-HTT variants in the coding regions, 3' untranslated region (3' UTR), and introns adjacent to each exon could also contribute to treatment response. Therefore, we performed a sequencing analysis of the SLC6A4 gene (coding for 5-HTT) and investigated the association between variants detected in this study and the antidepressant response to SSRI/SNRI in 201 Japanese depressive patients. Seventeen novel mutations were identified by sequencing analysis. We found that the polymorphism G2563T (rs3813034) as a tag single-nucleotide polymorphism of IVS9 A-90G (rs140701), G2356T (rs1042173), and A3641C (rs7224199) is associated with interindividual variability of SSRI/SNRI efficacy at week 6, independent from clinical variables and effect of 5-HTT LPR (P < 0.001 by multiple regression analysis). This polymorphism could help determine individualized SSRI/SNRI treatments for depressive patients in combination with 5-HTT LPR.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
medicine.drug_class
Serotonin and Noradrenaline Reuptake Inhibitor
Polymorphism, Single Nucleotide
Regression Analysi
SLC6A4
03 medical and health sciences
0302 clinical medicine
SSRI/SNRI
Internal medicine
mental disorders
Humans
Medicine
Pharmacology (medical)
Serotonin and Noradrenaline Reuptake Inhibitors
Polymorphism
Serotonin Uptake Inhibitors
Serotonin transporter
Serotonin–norepinephrine reuptake inhibitor
Serotonin Plasma Membrane Transport Proteins
Individualized medicine
Depressive Disorder, Major
biology
business.industry
Middle Aged
Serotonin Uptake Inhibitor
Psychiatry and Mental health
Treatment Outcome
030104 developmental biology
Endocrinology
Norepinephrine transporter
Sequence Analysi
biology.protein
Regression Analysis
Antidepressant
Female
Serotonin
business
Reuptake inhibitor
Sequence Analysis
Selective Serotonin Reuptake Inhibitors
Serotonin Plasma Membrane Transport Protein
030217 neurology & neurosurgery
Human
Subjects
Details
- ISSN :
- 02710749
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Psychopharmacology
- Accession number :
- edsair.doi.dedup.....56164b138f74ab9eb3fe555ccfa5fd61