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Klyflaccicembranols A–I, New Cembranoids from the Soft Coral Klyxum flaccidum
- Source :
- Marine Drugs; Volume 15; Issue 1; Pages: 23, Marine Drugs, Marine Drugs, Vol 15, Iss 1, p 23 (2017)
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- New cembranoids klyflaccicembranols A–I (1–9), along with gibberosene D (10), have been isolated from the organic extract of a Formosan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analyses, including 2D NMR spectroscopy, and spectral data comparison with related structures. The cytotoxicity of the isolated metabolites, as well as their nitric oxide (NO) inhibitory activity, were evaluated and reported. Metabolites 2, 4, 6, 8 and 9 were found to exhibit variable activities against a limited panel of cancer cell lines in a range of IC50 16.5–49.4 μM. Among the tested cembranoids, compounds 4, 5, 6, and 9 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages at a dose of 50 μg/mL.
- Subjects :
- Lipopolysaccharides
Magnetic Resonance Spectroscopy
Stereochemistry
soft coral
Klyxum flaccidum
cembranoid
NO inhibition
cytotoxicity
Coral
Pharmaceutical Science
Biology
Nitric Oxide
01 natural sciences
Article
Nitric oxide
chemistry.chemical_compound
Mice
Cell Line, Tumor
Drug Discovery
Animals
Humans
No production
Cytotoxicity
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
IC50
Biological Products
010405 organic chemistry
Macrophages
Anthozoa
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Coal
lcsh:Biology (General)
chemistry
A549 Cells
Cancer cell lines
Drug Screening Assays, Antitumor
K562 Cells
Two-dimensional nuclear magnetic resonance spectroscopy
HT29 Cells
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Database :
- OpenAIRE
- Journal :
- Marine Drugs; Volume 15; Issue 1; Pages: 23
- Accession number :
- edsair.doi.dedup.....561724bd001d603ada17e73077a67d97
- Full Text :
- https://doi.org/10.3390/md15010023