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Micro-endoscopic In Vivo Monitoring in the Blood and Lymphatic Vessels of the Oral Cavity after Radiation Therapy
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2019
- Publisher :
- Ivyspring International Publisher, 2019.
-
Abstract
- Radiotherapy, although used worldwide for the treatment of head, neck, and oral cancers, causes acute complications, including effects on vasculature and immune response due to cellular stress. Thus, the ability to diagnose side-effects and monitor vascular response in real-time during radiotherapy would be highly beneficial for clinical and research applications. In this study, recently-developed fluorescence micro-endoscopic technology provides non-invasive, high-resolution, real-time imaging at the cellular level. Moreover, with the application of high-resolution imaging technologies and micro-endoscopy, which enable improved monitoring of adverse effects in GFP-expressing mouse models, changes in the oral vasculature and lymphatic vessels are quantified in real time for 10 days following a mild localized single fractionation, 10 Gy radiotherapy treatments. Fluorescence micro-endoscopy enables quantification of the cardiovascular recovery and immune response, which shows short-term reduction in mean blood flow velocity, in lymph flow, and in transient immune infiltration even after this mild radiation dose, in addition to long-term reduction in blood vessel capacity. The data provided may serve as a reference for the expected cellular-level physiological, cardiovascular, and immune changes in animal disease models after radiotherapy.
- Subjects :
- Pathology
medicine.medical_specialty
medicine.medical_treatment
microendoscopy
Mice
03 medical and health sciences
0302 clinical medicine
Immune system
fluorescence imaging
In vivo
medicine
Animals
Humans
mouse models
Radiation Injuries
Mean Blood Flow Velocity
Adverse effect
radiotherapy
Lymphatic Vessels
Mouth
business.industry
Head and neck cancer
Endoscopy
General Medicine
medicine.disease
Radiation therapy
medicine.anatomical_structure
Lymphatic system
Head and Neck Neoplasms
head and neck cancer
Mouth Neoplasms
030211 gastroenterology & hepatology
Dose Fractionation, Radiation
business
Research Paper
Blood vessel
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....562f72c34d479823100c178db60e9051