Median facial cleft syndrome in half-sisters. Dilemmas in genetic counseling

Two infant gids with median facial cleft syndrome are described. The patients were the children of the same mother but of different fathers. None of the parents had the same or similar malformations. The occurrence of this rare syndrome in half-sisters is difficult to explain; it poses questions about etiology, usually not considered if malformation syndromes are seen in sisters who are the offspring of the same mother and father, both unaffected.