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Clinicopathological predictors of survival in resected primary lung adenocarcinoma
- Source :
- Journal of Clinical Pathology. 75:310-315
- Publication Year :
- 2021
- Publisher :
- BMJ, 2021.
-
Abstract
- AimsPrimary lung adenocarcinoma consists of a spectrum of clinical and pathological subtypes that may impact on overall survival (OS). Our study aims to evaluate the impact of adenocarcinoma subtype and intra-alveolar spread on survival after anatomical lung resection and identify different prognostic factors based on stage and histological subtype.MethodsNewly diagnosed patients undergoing anatomical lung resections without induction therapy, for pT1-3, N0-2 lung adenocarcinoma from April 2011 to March 2013, were included. The effect of clinical–pathological factors on survival was retrospectively assessed.ResultsTwo hundred and sixty-two patients were enrolled. The 1-year, 3-year and 5-year OS were 88.8%, 64.3% and 51.1%, respectively. Univariate analysis showed lymphovascular, parietal pleural and chest wall invasion to confer a worse 1-year and 5-year prognosis (all pIIa, lymphovascular invasion (p=0.002) and intra-alveolar spread (p=0.009) as significant independent predictors of worse OS. Co-presence of intra-alveolar spread and solid predominance significantly reduced OS. Disease-free survival (DFS) was reduced with parietal pleural (p=0.0007) and chest wall invasion (pConclusionsOur study demonstrates that solid predominant adenocarcinoma, intra-alveolar spread and lymphovascular invasion confer a worse prognosis and should be used as a prognostic tool to determine appropriate adjuvant treatment.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Lung Neoplasms
Lymphovascular invasion
Adenocarcinoma of Lung
Adenocarcinoma
Gastroenterology
Disease-Free Survival
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
Carcinoma
Humans
Medicine
Stage (cooking)
Lung
Pathological
Neoplasm Staging
Retrospective Studies
Univariate analysis
business.industry
General Medicine
Prognosis
medicine.disease
Lymphovascular
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 14724146 and 00219746
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....563cd670db343a6a31457c3b832c4ac3