Back to Search
Start Over
Strengths and weaknesses of in vitro assays for estrogenic and androgenic activity
- Source :
- Best Practice & Research Clinical Endocrinology & Metabolism. 20:15-33
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The endocrine and reproductive effects of xenobiotics are believed to be due to (1) their mimicking the effects of endogenous hormones; (2) their antagonizing the effects of endogenous hormones; (3) their altering the pattern of synthesis and metabolism of natural hormones; and (4) their modifying hormone receptor levels. It has been suggested that endocrine disruptors may play a role in the decrease in human semen quantity and quality, an increase in the anomalies of male genital tract, and an increase in the testicular and breast cancer incidence during the last 50 years. Testing these hypotheses will require: (1) identifying estrogen and androgen agonists and antagonists among the chemicals present in the environment; (2) assessing the interactions among the endocrine disruptors to which humans are exposed; and (3) finding markers of estrogen (and androgen) exposure. The development of fast and sensitive bioassays is central to the achievement of these three goals.
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Antiandrogens
Endocrinology, Diabetes and Metabolism
Drug Evaluation, Preclinical
Breast Neoplasms
Endocrine Disruptors
Biology
Binding, Competitive
Cell Line
Endocrinology
Genes, Reporter
Cell Line, Tumor
Internal medicine
medicine
Animals
Humans
Endocrine system
Cell Proliferation
Dose-Response Relationship, Drug
Estrogen Antagonists
Estrogen Receptor alpha
In vitro toxicology
Androgen Antagonists
Estrogens
Androgen
Receptors, Estrogen
Estrogen
Hormone receptor
Androgens
Biological Assay
Female
Estrogen receptor alpha
Hormone
Subjects
Details
- ISSN :
- 1521690X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Best Practice & Research Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....565901c1a34b4dae107988bf0d6a57f4