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Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair
- Source :
- BioMed Research International, BioMed Research International, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles. These gasotransmitters have multiple functional roles in the body including physiologic and pathologic functions with respect to the cellular or tissue quantities of these gases. Gasotransmitters were originally known to have only detrimental and noxious effects in the body but that notion has much changed with years; vast studies demonstrated that these gasotransmitters are precisely involved in the normal physiological functioning of the body. From neuromodulation, oxidative stress subjugation, and cardiovascular tone regulation to immunomodulation, these gases perform critical roles, which, should they deviate from the norm, can trigger the genesis of a number of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The purpose of this review is to discuss at great length physical and chemical properties and physiological actions of H2S, NO, and CO as well as shedding light on recently researched molecular targets. We particularly put emphasis on the roles in neuronal inflammation and neurodegeneration and neuronal repair.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
lcsh:Medicine
Inflammation
Review Article
Biology
Nitric Oxide
medicine.disease_cause
Cardiovascular System
General Biochemistry, Genetics and Molecular Biology
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Alzheimer Disease
medicine
Humans
Hydrogen Sulfide
Gasotransmitters
Neuroinflammation
Neurons
Carbon Monoxide
General Immunology and Microbiology
lcsh:R
Neurodegeneration
Parkinson Disease
General Medicine
medicine.disease
Neuromodulation (medicine)
Oxidative Stress
030104 developmental biology
chemistry
Alzheimer's disease
medicine.symptom
Neuroscience
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....566dd2a0bab386483537b3850f134ea8