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Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation
- Source :
- Polymeris, A A, Macha, K, Paciaroni, M, Wilson, D, Koga, M, Cappellari, M, Schaedelin, S, Zietz, A, Peters, N, Seiffge, D J, Haupenthal, D, Gassmann, L, De Marchis, G M, Wang, R, Gensicke, H, Stoll, S, Thilemann, S, Avramiotis, N S, Bonetti, B, Tsivgoulis, G, Ambler, G, Alberti, A, Yoshimura, S, Brown, M M, Shiozawa, M, Lip, G Y H, Venti, M, Acciarresi, M, Tanaka, K, Mosconi, M G, Takagi, M, Jäger, R H, Muir, K, Inoue, M, Schwab, S, Bonati, L H, Lyrer, P A, Toyoda, K, Caso, V, Werring, D J, Kallmünzer, B, Engelter, S T & NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF and Verona Registry collaborators 2022, ' Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation ', Annals of Neurology, vol. 91, no. 1, pp. 78-88 . https://doi.org/10.1002/ana.26267, Polymeris, Alexandros A; Macha, Kosmas; Paciaroni, Maurizio; Wilson, Duncan; Koga, Masatoshi; Cappellari, Manuel; Schaedelin, Sabine; Zietz, Annaelle; Peters, Nils; Seiffge, David J.; Haupenthal, David; Gassmann, Luise; De Marchis, Gian Marco; Wang, Ruihao; Gensicke, Henrik; Stoll, Svenja; Thilemann, Sebastian; Avramiotis, Nikolaos S; Bonetti, Bruno; Tsivgoulis, Georgios; ... (2022). Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation. Annals of neurology, 91(1), pp. 78-88. Wiley-Blackwell 10.1002/ana.26267
- Publication Year :
- 2022
-
Abstract
- Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (≥85y = 0.65, 95%-CI [0.52, 0.81]) and < 85 years (HR = 0.79, 95%-CI [0.66, 0.95]) in simple (p interaction = 0.129), adjusted (p interaction = 0.094) or weighted (p interaction = 0.512) models. Analyses on recurrent stroke, ICH and death separately were consistent with the primary analysis, as were sensitivity analyses using age dichotomized at 90 years and as a continuous variable. DOAC had a similar net clinical benefit in patients aged ≥85 (+1.73 to +2.66) and < 85 years (+1.90 to +3.36 events/100 patient-years for ICH-weights 1.5 to 3.1). Interpretation: The favorable profile of DOAC over VKA in patients with AF and recent stroke was maintained in the oldest old. ANN NEUROL 2021.
- Subjects :
- Male
medicine.medical_specialty
Vitamin K
medicine.drug_class
610 Medicine & health
Aged, 80 and over
Atrial Fibrillation
Factor Xa Inhibitors
Female
Humans
Stroke
Continuous variable
Internal medicine
80 and over
medicine
Aged
Proportional hazards model
business.industry
Anticoagulant
Confounding
Atrial fibrillation
Patient data
medicine.disease
Oldest old
Neurology
Neurology (clinical)
610 Medizin und Gesundheit
business
Subjects
Details
- Language :
- English
- ISSN :
- 03645134
- Database :
- OpenAIRE
- Journal :
- Polymeris, A A, Macha, K, Paciaroni, M, Wilson, D, Koga, M, Cappellari, M, Schaedelin, S, Zietz, A, Peters, N, Seiffge, D J, Haupenthal, D, Gassmann, L, De Marchis, G M, Wang, R, Gensicke, H, Stoll, S, Thilemann, S, Avramiotis, N S, Bonetti, B, Tsivgoulis, G, Ambler, G, Alberti, A, Yoshimura, S, Brown, M M, Shiozawa, M, Lip, G Y H, Venti, M, Acciarresi, M, Tanaka, K, Mosconi, M G, Takagi, M, Jäger, R H, Muir, K, Inoue, M, Schwab, S, Bonati, L H, Lyrer, P A, Toyoda, K, Caso, V, Werring, D J, Kallmünzer, B, Engelter, S T & NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF and Verona Registry collaborators 2022, ' Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation ', Annals of Neurology, vol. 91, no. 1, pp. 78-88 . https://doi.org/10.1002/ana.26267, Polymeris, Alexandros A; Macha, Kosmas; Paciaroni, Maurizio; Wilson, Duncan; Koga, Masatoshi; Cappellari, Manuel; Schaedelin, Sabine; Zietz, Annaelle; Peters, Nils; Seiffge, David J.; Haupenthal, David; Gassmann, Luise; De Marchis, Gian Marco; Wang, Ruihao; Gensicke, Henrik; Stoll, Svenja; Thilemann, Sebastian; Avramiotis, Nikolaos S; Bonetti, Bruno; Tsivgoulis, Georgios; ... (2022). Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation. Annals of neurology, 91(1), pp. 78-88. Wiley-Blackwell 10.1002/ana.26267 <http://dx.doi.org/10.1002/ana.26267>
- Accession number :
- edsair.doi.dedup.....567a3fa844c4c8db9d79ea0a5c89cf34