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Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation
Authors :
Stefania Galimberti Francesca Graziano Andrew I R Maas Giulia Isernia Fiona Lecky Sonia Jain Xiaoying Sun Raquel C Gardner Sabrina R Taylor Amy J Markowitz Geoffrey T Manley Maria Grazia Valsecchi Giuseppe Bellelli Giuseppe Citerio Cecilia Ackerlund Hadie Adams Krisztina Amrein Nada Andelic Lasse Andreassen Audny Anke Anna Antoni Gérard Audibert Philippe Azouvi Maria Luisa Azzolini Ronald Bartels Pál Barzó Romuald Beauvais Ronny Beer Bo-Michael Bellander Antonio Belli Habib Benali Maurizio Berardino Luigi Beretta Morten Blaabjerg Peter Bragge Alexandra Brazinova Vibeke Brinck Joanne Brooker Camilla Brorsson Andras Buki Monika Bullinger Manuel Cabeleira Alessio Caccioppola Emiliana Calappi Maria Rosa Calvi Peter Cameron Guillermo Carbayo Lozano Marco Carbonara Ana M. Castaño-León Simona Cavallo Giorgio Chevallard Arturo Chieregato Hans Clusmann Mark Steven Coburn Jonathan Coles Jamie D. Cooper Marta Correia Amra Covic Nicola Curry Endre Czeiter Marek Czosnyka Claire Dahyot-Fizelier Paul Dark Helen Dawes Véronique De Keyser Vincent Degos Francesco Della Corte Hugo den Boogert Bart Depreitere Đula Đilvesi Abhishek Dixit Emma Donoghue Jens Dreier Guy-Loup Dulière Ari Ercole Patrick Esser Erzsébet Ezer Martin Fabricius Valery L. Feigin Kelly Foks Shirin Frisvold Alex Furmanov Pablo Gagliardo Damien Galanaud Dashiell Gantner Guoyi Gao Pradeep George Alexandre Ghuysen Lelde Giga Ben Glocker Jagoš Golubovic Pedro A. Gomez Johannes Gratz Benjamin Gravesteijn Francesca Grossi Russell L. Gruen Deepak Gupta Juanita A. Haagsma Iain Haitsma Raimund Helbok Eirik Helseth Lindsay Horton Jilske Huijben Peter J. Hutchinson Bram Jacobs Stefan Jankowski Mike Jarrett Ji-yao Jiang Faye Johnson Kelly Jones Mladen Karan Angelos G. Kolias Erwin Kompanje Daniel Kondziella Lars-Owe Koskinen Noémi Kovács Ana Kowark Alfonso Lagares Linda Lanyon Steven Laureys Didier Ledoux Rolf Lefering Valerie Legrand Aurelie Lejeune Leon Levi Roger Lightfoot Hester Lingsma Marc Maegele Marek Majdan Alex Manara Hugues Maréchal Costanza Martino Julia Mattern Charles McFadyen Catherine McMahon Béla Melegh David Menon Tomas Menovsky Ana Mikolic Benoit Misset Visakh Muraleedharan Lynnette Murray Ancuta Negru David Nelson Virginia Newcombe Daan Nieboer József Nyirádi Matej Oresic Fabrizio Ortolano Olubukola Otesile Aarno Palotie Paul M. Parizel Jean-François Payen Natascha Perera Vincent Perlbarg Paolo Persona Wilco Peul Anna Piippo-Karjalainen Matti Pirinen Dana Pisica Horia Ples Suzanne Polinder Inigo Pomposo Jussi P. Posti Louis Puybasset Andreea Radoi Arminas Ragauskas Rahul Raj Malinka Rambadagalla Veronika Rehorčíková Isabel Retel Helmrich Jonathan Rhodes Sylvia Richardson Sophie Richter Samuli Ripatti Saulius Rocka Cecilie Roe Olav Roise Jeffrey Rosenfeld Christina Rosenlund Guy Rosenthal Rolf Rossaint Sandra Rossi Daniel Rueckert Martin Rusnák Juan Sahuquillo Oliver Sakowitz Renan Sanchez-Porras Janos Sandor Nadine Schäfer Silke Schmidt Herbert Schoechl Guus Schoonman Rico Frederik Schou Elisabeth Schwendenwein Charlie Sewalt Ranjit D. Singh Toril Skandsen Peter Smielewski Abayomi Sorinola Emmanuel Stamatakis Simon Stanworth Robert Stevens William Stewart Ewout W. Steyerberg Nino Stocchetti Nina Sundström Riikka Takala Viktória Tamás Tomas Tamosuitis Mark Steven Taylor Braden Te Ao Olli Tenovuo Alice Theadom Matt Thomas Dick Tibboel Marjolijn Timmers Christos Tolias Tony Trapani Cristina Maria Tudora Andreas Unterberg Peter Vajkoczy Egils Valeinis Shirley Vallance Zoltán Vámos Mathieu van der Jagt Joukje van der Naalt Gregory Van der Steen Jeroen T.J.M. van Dijck Inge A. van Erp Thomas A. van Essen Wim Van Hecke Caroline van Heugten Dominique Van Praag Ernest van Veen Roel van Wijk Thijs Vande Vyvere Alessia Vargiolu Emmanuel Vega Kimberley Velt Jan Verheyden Paul M. Vespa Anne Vik Rimantas Vilcinis Victor Volovici Nicole von Steinbüchel Daphne Voormolen Peter Vulekovic Kevin K.W. Wang Eveline Wiegers Guy Williams Lindsay Wilson Stefan Wolf Zhihui Yang Peter Ylén Alexander Younsi Frederick A. Zeiler Agate Ziverte Tommaso Zoerle Opeolu Adeoye Neeraj Badjatia Jason Barber Michael Bergin Kim Boase Yelena Bodien Randall Chesnut John Corrigan Karen Crawford Ramon Diaz-Arrastia Sureyya Dikmen Ann-Christine Duhaime Richard Ellenbogen Venkata Feeser Adam R Ferguson Brandon Foreman Etienne Gaudette Joseph Giacino Luis Gonzalez Shankar Gopinath Ramesh Grandhi Rao Gullapalli Claude Hemphill Gillian Hotz Russell Huie Ruchira Jha C. Dirk Keene Ryan Kitagawa Frederick Korley Joel Kramer Natalie Kreitzer Harvey Levin Chris Lindsell Joan Machamer Christopher Madden Alastair Martin Thomas McAllister Michael McCrea Randall Merchant Pratik Mukherjee Lindsay Nelson Laura B. Ngwenya Florence Noel Amber Nolan David Okonkwo Eva Palacios Daniel Perl Ava Puccio Miri Rabinowitz Claudia Robertson Richard Ben Rodgers Jonathan Rosand Eric Rosenthal Angelle Sander Danielle Sandsmark Gabriella Sugar Andrea Schneider David Schnyer Seth Seabury Mark Sherer Murray Stein Nancy Temkin Arthur Toga Abel Torres-Espin Alex Valadka Mary Vassar Kevin Wang Vincent Wang John K. Yue Esther Yuh Ross Zafonte Galimberti, S Graziano, F Maas, A Isernia, G Lecky, F Jain, S Sun, X Gardner, R Taylor, S Markowitz, A Manley, G Valsecchi, M Bellelli, G Citerio, G Ackerlund, C Adams, H Amrein, K Andelic, N Andreassen, L Anke, A Antoni, A Audibert, G Azouvi, P Azzolini, M Bartels, R Barzo, P Beauvais, R Beer, R Bellander, B Belli, A Benali, H Berardino, M Beretta, L Blaabjerg, M Bragge, P Brazinova, A Brinck, V Brooker, J Brorsson, C Buki, A Bullinger, M Cabeleira, M Caccioppola, A Calappi, E Calvi, M Cameron, P Carbayo Lozano, G Carbonara, M Castano-Leon, A Cavallo, S Chevallard, G Chieregato, A Clusmann, H Coburn, M Coles, J Cooper, J Correia, M Covic, A Curry, N Czeiter, E Czosnyka, M Dahyot-Fizelier, C Dark, P Dawes, H De Keyser, V Degos, V Della Corte, F den Boogert, H Depreitere, B Dilvesi, D Dixit, A Donoghue, E Dreier, J Duliere, G Ercole, A Esser, P Ezer, E Fabricius, M Feigin, V Foks, K Frisvold, S Furmanov, A Gagliardo, P Galanaud, D Gantner, D Gao, G George, P Ghuysen, A Giga, L Glocker, B Golubovic, J Gomez, P Gratz, J Gravesteijn, B Grossi, F Gruen, R Gupta, D Haagsma, J Haitsma, I Helbok, R Helseth, E Horton, L Huijben, J Hutchinson, P Jacobs, B Jankowski, S Jarrett, M Jiang, J Johnson, F Jones, K Karan, M Kolias, A Kompanje, E Kondziella, D Koskinen, L Kovacs, N Kowark, A Lagares, A Lanyon, L Laureys, S Ledoux, D Lefering, R Legrand, V Lejeune, A Levi, L Lightfoot, R Lingsma, H Maegele, M Majdan, M Manara, A Marechal, H Martino, C Mattern, J Mcfadyen, C Mcmahon, C Melegh, B Menon, D Menovsky, T Mikolic, A Misset, B Muraleedharan, V Murray, L Negru, A Nelson, D Newcombe, V Nieboer, D Nyiradi, J Oresic, M Ortolano, F Otesile, O Palotie, A Parizel, P Payen, J Perera, N Perlbarg, V Persona, P Peul, W Piippo-Karjalainen, A Pirinen, M Pisica, D Ples, H Polinder, S Pomposo, I Posti, J Puybasset, L Radoi, A Ragauskas, A Raj, R Rambadagalla, M Rehorcikova, V Retel Helmrich, I Rhodes, J Richardson, S Richter, S Ripatti, S Rocka, S Roe, C Roise, O Rosenfeld, J Rosenlund, C Rosenthal, G Rossaint, R Rossi, S Rueckert, D Rusnak, M Sahuquillo, J Sakowitz, O Sanchez-Porras, R Sandor, J Schafer, N Schmidt, S Schoechl, H Schoonman, G Schou, R Schwendenwein, E Sewalt, C Singh, R Skandsen, T Smielewski, P Sorinola, A Stamatakis, E Stanworth, S Stevens, R Stewart, W Steyerberg, E Stocchetti, N Sundstrom, N Takala, R Tamas, V Tamosuitis, T Taylor, M Te Ao, B Tenovuo, O Theadom, A Thomas, M Tibboel, D Timmers, M Tolias, C Trapani, T Tudora, C Unterberg, A Vajkoczy, P Valeinis, E Vallance, S Vamos, Z van der Jagt, M van der Naalt, J Van der Steen, G van Dijck, J van Erp, I van Essen, T Van Hecke, W van Heugten, C Van Praag, D van Veen, E van Wijk, R Vande Vyvere, T Vargiolu, A Vega, E Velt, K Verheyden, J Vespa, P Vik, A Vilcinis, R Volovici, V von Steinbuchel, N Voormolen, D Vulekovic, P Wang, K Wiegers, E Williams, G Wilson, L Wolf, S Yang, Z Ylen, P Younsi, A Zeiler, F Ziverte, A Zoerle, T Adeoye, O Badjatia, N Barber, J Bergin, M Boase, K Bodien, Y Chesnut, R Corrigan, J Crawford, K Diaz-Arrastia, R Dikmen, S Duhaime, A Ellenbogen, R Feeser, V Ferguson, A Foreman, B Gaudette, E Giacino, J Gonzalez, L Gopinath, S Grandhi, R Gullapalli, R Hemphill, C Hotz, G Huie, R Jha, R Keene, C Kitagawa, R Korley, F Kramer, J Kreitzer, N Levin, H Lindsell, C Machamer, J Madden, C Martin, A Mcallister, T Mccrea, M Merchant, R Mukherjee, P Nelson, L Ngwenya, L Noel, F Nolan, A Okonkwo, D Palacios, E Perl, D Puccio, A Rabinowitz, M Robertson, C Rodgers, R Rosand, J Rosenthal, E Sander, A Sandsmark, D Sugar, G Schneider, A Schnyer, D Seabury, S Sherer, M Stein, M Temkin, N Toga, A Torres-Espin, A Valadka, A Vassar, M Wang, V Yue, J Yuh, E Zafonte, R Molecular Neuroscience and Ageing Research (MOLAR) CENTER-TBI TRACK-TBI Participants and Investigators Galimberti, S. Graziano, F. Maas, A. I. R. Isernia, G. Lecky, F. Jain, S. Sun, X. Gardner, R. C. Taylor, S. R. Markowitz, A. J. Manley, G. T. Valsecchi, M. G. Bellelli, G. Citerio, G. Ackerlund, C. Adams, H. Amrein, K. Andelic, N. Andreassen, L. Anke, A. Antoni, A. Audibert, G. Azouvi, P. Azzolini, M. L. Bartels, R. Barzo, P. Beauvais, R. Beer, R. Bellander, B. -M. Belli, A. Benali, H. Berardino, M. Beretta, L. Blaabjerg, M. Bragge, P. Brazinova, A. Brinck, V. Brooker, J. Brorsson, C. Buki, A. Bullinger, M. Cabeleira, M. Caccioppola, A. Calappi, E. Calvi, M. R. Cameron, P. Carbayo Lozano, G. Carbonara, M. Castano-Leon, A. M. Cavallo, S. Chevallard, G. Chieregato, A. Clusmann, H. Coburn, M. S. Coles, J. Cooper, J. D. Correia, M. Covic, A. Curry, N. Czeiter, E. Czosnyka, M. Dahyot-Fizelier, C. Dark, P. Dawes, H. De Keyser, V. Degos, V. Della Corte, F. den Boogert, H. Depreitere, B. Dilvesi, D. Dixit, A. Donoghue, E. Dreier, J. Duliere, G. -L. Ercole, A. Esser, P. Ezer, E. Fabricius, M. Feigin, V. L. Foks, K. Frisvold, S. Furmanov, A. Gagliardo, P. Galanaud, D. Gantner, D. Gao, G. George, P. Ghuysen, A. Giga, L. Glocker, B. Golubovic, J. Gomez, P. A. Gratz, J. Gravesteijn, B. Grossi, F. Gruen, R. L. Gupta, D. Haagsma, J. A. Haitsma, I. Helbok, R. Helseth, E. Horton, L. Huijben, J. Hutchinson, P. J. Jacobs, B. Jankowski, S. Jarrett, M. Jiang, J. -Y. Johnson, F. Jones, K. Karan, M. Kolias, A. G. Kompanje, E. Kondziella, D. Koskinen, L. -O. Kovacs, N. Kowark, A. Lagares, A. Lanyon, L. Laureys, S. Ledoux, D. Lefering, R. Legrand, V. Lejeune, A. Levi, L. Lightfoot, R. Lingsma, H. Maegele, M. Majdan, M. Manara, A. Marechal, H. Martino, C. Mattern, J. Mcfadyen, C. Mcmahon, C. Melegh, B. Menon, D. Menovsky, T. Mikolic, A. Misset, B. Muraleedharan, V. Murray, L. Negru, A. Nelson, D. Newcombe, V. Nieboer, D. Nyiradi, J. Oresic, M. Ortolano, F. Otesile, O. Palotie, A. Parizel, P. M. Payen, J. -F. Perera, N. Perlbarg, V. Persona, P. Peul, W. Piippo-Karjalainen, A. Pirinen, M. Pisica, D. Ples, H. Polinder, S. Pomposo, I. Posti, J. P. Puybasset, L. Radoi, A. Ragauskas, A. Raj, R. Rambadagalla, M. Rehorcikova, V. Retel Helmrich, I. Rhodes, J. Richardson, S. Richter, S. Ripatti, S. Rocka, S. Roe, C. Roise, O. Rosenfeld, J. Rosenlund, C. Rosenthal, G. Rossaint, R. Rossi, S. Rueckert, D. Rusnak, M. Sahuquillo, J. Sakowitz, O. Sanchez-Porras, R. Sandor, J. Schafer, N. Schmidt, S. Schoechl, H. Schoonman, G. Schou, R. F. Schwendenwein, E. Sewalt, C. Singh, R. D. Skandsen, T. Smielewski, P. Sorinola, A. Stamatakis, E. Stanworth, S. Stevens, R. Stewart, W. Steyerberg, E. W. Stocchetti, N. Sundstrom, N. Takala, R. Tamas, V. Tamosuitis, T. Taylor, M. S. Te Ao, B. Tenovuo, O. Theadom, A. Thomas, M. Tibboel, D. Timmers, M. Tolias, C. Trapani, T. Tudora, C. M. Unterberg, A. Vajkoczy, P. Valeinis, E. Vallance, S. Vamos, Z. van der Jagt, M. van der Naalt, J. Van der Steen, G. van Dijck, J. T. J. M. van Erp, I. A. van Essen, T. A. Van Hecke, W. van Heugten, C. Van Praag, D. van Veen, E. van Wijk, R. Vande Vyvere, T. Vargiolu, A. Vega, E. Velt, K. Verheyden, J. Vespa, P. M. Vik, A. Vilcinis, R. Volovici, V. von Steinbuchel, N. Voormolen, D. Vulekovic, P. Wang, K. K. W. Wiegers, E. Williams, G. Wilson, L. Wolf, S. Yang, Z. Ylen, P. Younsi, A. Zeiler, F. A. Ziverte, A. Zoerle, T. Adeoye, O. Badjatia, N. Barber, J. Bergin, M. Boase, K. Bodien, Y. Chesnut, R. Corrigan, J. Crawford, K. Diaz-Arrastia, R. Dikmen, S. Duhaime, A. -C. Ellenbogen, R. Feeser, V. Ferguson, A. R. Foreman, B. Gaudette, E. Giacino, J. Gonzalez, L. Gopinath, S. Grandhi, R. Gullapalli, R. Hemphill, C. Hotz, G. Huie, R. Jha, R. Keene, C. D. Kitagawa, R. Korley, F. Kramer, J. Kreitzer, N. Levin, H. Lindsell, C. Machamer, J. Madden, C. Martin, A. Mcallister, T. Mccrea, M. Merchant, R. Mukherjee, P. Nelson, L. Ngwenya, L. B. Noel, F. Nolan, A. Okonkwo, D. Palacios, E. Perl, D. Puccio, A. Rabinowitz, M. Robertson, C. Rodgers, R. B. Rosand, J. Rosenthal, E. Sander, A. Sandsmark, D. Sugar, G. Schneider, A. Schnyer, D. Seabury, S. Sherer, M. Stein, M. Temkin, N. Toga, A. Torres-Espin, A. Valadka, A. Vassar, M. Wang, K. Wang, V. Yue, J. K. Yuh, E. Zafonte, R.
Source :
The Lancet Neurology, 21(2), 153-162. ELSEVIER SCIENCE INC, The lancet neurology, Lancet Neurology, 21(2):35065038, 153-162. ELSEVIER SCIENCE INC, Galimberti, S, Graziano, F, Maas, A I R, Isernia, G, Lecky, F, Jain, S, Sun, X, Gardner, R C, Taylor, S R, Markowitz, A J, Manley, G T, Valsecchi, M G, Bellelli, G, Citerio, G, Ylén, P & CENTER-TBI and TRACK-TBI participants and investigators 2022, ' Effect of frailty on 6-month outcome after traumatic brain injury : A multicentre cohort study with external validation ', The Lancet Neurology, vol. 21, no. 2, pp. 153-162 . https://doi.org/10.1016/S1474-4422(21)00374-4
Publication Year :
2022
Publisher :
The Lancet Publishing Group, 2022.
Abstract
Background: Frailty is known to be associated with poorer outcomes in individuals admitted to hospital for medical conditions requiring intensive care. However, little evidence is available for the effect of frailty on patients’ outcomes after traumatic brain injury. Many frailty indices have been validated for clinical practice and show good performance to predict clinical outcomes. However, each is specific to a particular clinical context. We aimed to develop a frailty index to predict 6-month outcomes in patients after a traumatic brain injury. Methods: A cumulative deficit approach was used to create a novel frailty index based on 30 items dealing with disease states, current medications, and laboratory values derived from data available from CENTER-TBI, a prospective, longitudinal observational study of patients with traumatic brain injury presenting within 24 h of injury and admitted to a ward or an intensive care unit at 65 centres in Europe between Dec 19, 2014, and Dec 17, 2017. From the individual cumulative CENTER-TBI frailty index (range 0–30), we obtained a standardised value (range 0–1), with high scores indicating higher levels of frailty. The effect of frailty on 6-month outcome evaluated with the extended Glasgow Outcome Scale (GOSE) was assessed through a proportional odds logistic model adjusted for known outcome predictors. An unfavourable outcome was defined as death or severe disability (GOSE score ≤4). External validation was performed on data from TRACK-TBI, a prospective observational study co-designed with CENTER-TBI, which enrolled patients with traumatic brain injury at 18 level I trauma centres in the USA from Feb 26, 2014, to July 27, 2018. CENTER-TBI is registered with ClinicalTrials.gov, NCT02210221; TRACK-TBI is registered at ClinicalTrials.gov, NCT02119182. Findings: 2993 participants (median age was 51 years [IQR 30–67], 2058 [69%] were men) were included in this analysis. The overall median CENTER-TBI frailty index score was 0·07 (IQR 0·03–0·15), with a median score of 0·17 (0·08–0·27) in older adults (aged ≥65 years). The CENTER-TBI frailty index score was significantly associated with the probability of an increasingly unfavourable outcome (cumulative odds ratio [OR] 1·03, 95% CI 1·02–1·04; p
Details
Language :
English
ISSN :
14744422
Database :
OpenAIRE
Journal :
The Lancet Neurology, 21(2), 153-162. ELSEVIER SCIENCE INC, The lancet neurology, Lancet Neurology, 21(2):35065038, 153-162. ELSEVIER SCIENCE INC, Galimberti, S, Graziano, F, Maas, A I R, Isernia, G, Lecky, F, Jain, S, Sun, X, Gardner, R C, Taylor, S R, Markowitz, A J, Manley, G T, Valsecchi, M G, Bellelli, G, Citerio, G, Ylén, P & CENTER-TBI and TRACK-TBI participants and investigators 2022, ' Effect of frailty on 6-month outcome after traumatic brain injury : A multicentre cohort study with external validation ', The Lancet Neurology, vol. 21, no. 2, pp. 153-162 . https://doi.org/10.1016/S1474-4422(21)00374-4
Accession number :
edsair.doi.dedup.....568c404e0b0bf52b9b9159f1bab163df
Full Text :
https://doi.org/10.1016/S1474-4422(21)00374-4