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Blood eosinophilia and FEV1. Cross-sectional and longitudinal analyses
- Source :
- Am Rev Respir Dis, Am Rev Respir Dis, 1991, 143 (5 Pt 1), pp.987-92
- Publication Year :
- 1991
- Publisher :
- HAL CCSD, 1991.
-
Abstract
- International audience; A previous cross-sectional analysis of 1980 data from a population of working men in the Paris area has shown a significant relationship of blood eosinophilia to a reduced FEV1 among nonsmokers, remaining after excluding men with a history of asthma. In the present report, we reexamine this relationship, after taking into account asthma, bronchial hyperresponsiveness, and positive skin prick tests, using data collected in 1985 in a subsample of 363 men from the initial population. Blood eosinophilia, defined by 5% or more eosinophils or by 250 or more eosinophils per cubic millimeter appeared to be associated with a lower FEV1, primarily in nonsmokers. A difference of approximately 0.40 L was observed in never-smokers with eosinophilia (greater than or equal to 5% of eosinophils) compared with those without. This association persisted after exclusion of subjects with atopy, asthma, and bronchial hyperresponsiveness. Longitudinally, no significant association was observed between 1980 eosinophilia and the annual FEV1 decline between 1980 and 1985, even in nonsmokers. The results of our cross-sectional analyses suggest that asthma or asthma-like disorder does not explain the association between eosinophilia and FEV1. The role of eosinophil in respiratory disorders may go beyond its intervention in allergy. Further longitudinal studies are needed to better understand discrepancies between cross-sectional and longitudinal data and whether eosinophilia is a risk factor for chronic air-flow limitation.
- Subjects :
- Male
Allergy
MESH: Asthma
Atopy
0302 clinical medicine
Risk Factors
MESH: Risk Factors
Forced Expiratory Volume
Eosinophilia
Longitudinal Studies
030212 general & internal medicine
MESH: Longitudinal Studies
education.field_of_study
Smoking
MESH: Paris
respiratory system
medicine.anatomical_structure
Bronchial hyperresponsiveness
medicine.symptom
Adult
Pulmonary and Respiratory Medicine
Paris
MESH: Smoking
Population
MESH: Forced Expiratory Volume
MESH: Eosinophilia
03 medical and health sciences
MESH: Cross-Sectional Studies
MESH: Skin Tests
MESH: Lung Diseases, Obstructive
medicine
Humans
Lung Diseases, Obstructive
Risk factor
education
Skin Tests
Asthma
MESH: Humans
business.industry
MESH: Adult
Eosinophil
medicine.disease
MESH: Male
respiratory tract diseases
Cross-Sectional Studies
030228 respiratory system
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Immunology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Am Rev Respir Dis, Am Rev Respir Dis, 1991, 143 (5 Pt 1), pp.987-92
- Accession number :
- edsair.doi.dedup.....5697218a108855f5b38c087851722d10