Back to Search
Start Over
Some analogs of luteinizing hormone releasing hormone (LH-RH) having intense ovulation-inducing activity
- Source :
- Biochemical and biophysical research communications. 57(4)
- Publication Year :
- 1974
-
Abstract
- Five new analogs of luteinizing hormone releasing hormone (LH-RH), des-Gly10-[Ala6]-LH-RH-ethylamide, des-Gly10-[D-Ala6]-LH-RH-ethylamide, des-Gly10-[α-aminoisobutyric acid6]-LH-RH-ethylamide, des-Gly10-[Phe5, D-Ala6]-LH-RH-ethylamide and des-Gly10-[Ile5, D-Ala6]-LH-RH-ethylamide were synthesized and evaluated for the ovulation-inducing activity in the rat, and it was found that the analogs, des-Gly10-[D-Ala6]-LH-RH-ethylamide and des-Gly10-[Phe5, D-Ala6]-LH-RH-ethylamide, were 50 times or more active than the original molecule.
- Subjects :
- Ovulation
medicine.medical_specialty
Optical Rotation
media_common.quotation_subject
Biophysics
Biochemistry
Gonadotropin-Releasing Hormone
Structure-Activity Relationship
Estrus
Thyrotropin-releasing hormone receptor
Pregnancy
Internal medicine
medicine
Animals
Amino Acids
Molecular Biology
media_common
Chemistry
Cell Biology
Luteinizing Hormone
Chromatography, Ion Exchange
Rats
Endocrinology
Biological Assay
Female
Spectrophotometry, Ultraviolet
Chromatography, Thin Layer
Follicle Stimulating Hormone
Luteinizing hormone
Hormone
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 57
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....56a1c29a3d6ab64515459726c08de3f2