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Safety and efficacy of various concentrations of topical lidocaine gel for intravitreal injection

Safety and efficacy of various concentrations of topical lidocaine gel for intravitreal injection

Authors :
Renata Portella Nunes
Fernando M. Penha
Michel Eid Farah
Helio Francisco Shiroma
Jose Carlos Lorenzo
Astor Grumann
Eduardo Buchelle Rodrigues
Source :
Expert Opinion on Drug Safety. 13:1299-1303
Publication Year :
2014
Publisher :
Informa UK Limited, 2014.

Abstract

Intravitreal injection (IVT) is one of the most common vitreoretinal procedures, a large majority are performed with local anesthesia. The purpose of this study was to investigate the safety to the cornea and anesthetic efficacy of five concentrations of lidocaine gel.A prospective clinical trial was conducted testing lidocaine gel in five preparations: 2, 3.5, 5, 8 and 12%. Patients with macular degeneration, diabetic edema or retina vein occlusion were scheduled for intravitreal treatment received topical anesthesia with lidocaine gel 5 and 10 min before the procedure. Patients answered the visual analog scale for pain during the procedure. Corneal and conjunctival was evaluated using the Oxford scale.In total, 260 patients were randomized into five groups. The mean pain scores (± standard deviation) were 2.63 (± 1.68) in the 2% group, 2.08 (± 1.35) in the 3.5%; 2.00 (± 1.65) in the 5%, 1.93 (± 1.40) in the 8% and 1.83 (± 1.35) in the 12% group. Mean pain score among all groups was similar (p = 0.077). There was no significant difference between groups in regard to keratitis mean score (p = 0.897).Lidocaine gel at concentrations from 2 to 12% induced similar anesthetic effect for IVTs, without adverse effects on cornea and conjunctiva.

Details

ISSN :
1744764X and 14740338
Volume :
13
Database :
OpenAIRE
Journal :
Expert Opinion on Drug Safety
Accession number :
edsair.doi.dedup.....56a66baa9f0957e3ee079083ae2e6caa
Full Text :
https://doi.org/10.1517/14740338.2014.947261