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Transcriptional regulation of the mucosal immune system mediated by T-bet
- Source :
- Mucosal Immunology. 3:567-577
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The immune system faces the arduous task of defending the mucosal surfaces from invading pathogens, but must simultaneously repress responses against commensal organisms and other inert antigens that are abundant in the external environment, as inappropriate immune activation might expose the host to increased risk of autoimmunity. The behavior of individual immune cells is governed by the expression of transcription factors that are responsible for switching immune response genes on and off. T-bet (T-box expressed in T cells) has emerged as one of the key transcription factors responsible for controlling the fate of both innate and adaptive immune cells, and its expression in different immune cells found at mucosal surfaces is capable of dictating the critical balance between permitting robust host immunity and limiting susceptibility to autoimmunity and allergy.
- Subjects :
- T-Lymphocytes
animal diseases
Immunology
Autoimmunity
chemical and pharmacologic phenomena
Adaptive Immunity
Biology
Immunomodulation
Immune system
Antigen
Antigenic variation
Animals
Humans
Immunology and Allergy
Immunity, Mucosal
Th1-Th2 Balance
Innate immune system
Innate lymphoid cell
Cell Differentiation
biochemical phenomena, metabolism, and nutrition
Acquired immune system
Gene Expression Regulation
Mucosal immunology
bacteria
T-Box Domain Proteins
Subjects
Details
- ISSN :
- 19330219
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Mucosal Immunology
- Accession number :
- edsair.doi.dedup.....56c31845f8702eb7b1d51707385d9c7e