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HIV-2 viral tropism influences CD4+ T cell count regardless of viral load
- Source :
- UVaDOC. Repositorio Documental de la Universidad de Valladolid, instname, Journal of Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy; Vol 69
- Publication Year :
- 2014
- Publisher :
- Oxford University Press, 2014.
-
Abstract
- Producción Científica<br />Background:HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in compari-son with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails toprovide optimal CD4 recovery.Methods:We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viraltropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA.Results:From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%).Patients with X4 viruses had lower median CD4+cell counts than patients with R5 viruses [130 (17 – 210) versus359 (180 – 470) cells/mm3;P¼0.007]. This was true even considering only the subset of 19 patients on antiretro-viral therapy [94 (16 – 147) versus 184 (43 – 368) cells/mm3;P¼0.041]. In multivariate analysis, significant differ-ences in CD4+cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender,antiretroviral therapy and viral load.Conclusions:The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+cell counts, regard-less of antiretroviral treatment. Along with CD4+cell counts, viral tropism testing may assist decisions aboutwhen to initiate antiretroviral therapy in HIV-2-infected individuals.<br />Fundación Investigación y Educación en Sida. (RIS, ISCIII-RETICRD/12/0017/0031)<br />Fondo de Investigación Sanitaria (FIS, PI10/00520)<br />Ministerio de Salud Consumo y Bienestar Social (EC10/277)<br />Ministerio de Ciencia e Innovación (MICINN, SAF2010/22232)<br />El proyecto Europeo CHAIN (FP7-223131)
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
Microbiology (medical)
Multivariate analysis
Anti-HIV Agents
viruses
Cell
HIV Infections
HIV Envelope Protein gp120
Maraviroc
Acquired immunodeficiency syndrome (AIDS)
Cyclohexanes
HIV Fusion Inhibitors
Viral entry
32 Ciencias Médicas
Humans
Medicine
Pharmacology (medical)
Viremia
Pharmacology
Cd4 t cell
business.industry
virus diseases
Middle Aged
Triazoles
Viral Load
medicine.disease
Virology
Peptide Fragments
CD4 Lymphocyte Count
3. Good health
Carga proviral
Viral Tropism
Infectious Diseases
medicine.anatomical_structure
Spain
CCR5 Receptor Antagonists
HIV-2
Cohort
Immunology
Tissue tropism
RNA, Viral
Female
business
Viral load
Antagonistas
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- UVaDOC. Repositorio Documental de la Universidad de Valladolid, instname, Journal of Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy; Vol 69
- Accession number :
- edsair.doi.dedup.....56d244b5a6804c7c4fd8168f39ab2550