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Lipopolysaccharide inhibits the simultaneous establishment of LiCl-induced anticipatory nausea and intravascularly conditioned taste avoidance in the rat
- Source :
- Behavioural Brain Research. 232:278-286
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- This study examined the effects of the bacterial endotoxin, lipopolysaccharide (LPS), on the establishment of anticipatory nausea and conditioned taste avoidance in a simultaneous conditioning paradigm using an intravascular/intraperitoneal saccharin taste. 83 naive adult male Long-Evans rats were injected (intraperitoneal) with either 200 μg/kg LPS or 0.9% saline (NaCl), 90 min prior to ip treatment with either 64 mg/kg LiCl, 64 mg/kg LiCl + 2.0% saccharin, 0.9% NaCl, or 0.9% NaCl + 2.0% saccharin, and immediately placed into a distinctive context for 30 min (repeated over 4 conditioning days, spaced 72 h apart). 72 h following the final conditioning day, each animal was re-exposed to the context on a drug-free test day where orofacial responding was recorded. The next day, animals received a 24 h 2-bottle preference test with a choice between water and a palatable 0.2% saccharin solution. Results showed that LPS exposure, prior to LiCl or LiCl + Saccharin treatment, inhibited the establishment of anticipatory nausea, as evidenced by significantly lower conditioned gaping frequencies relative to animals pre-treated with NaCl followed by LiCl or LiCl + Saccharin. LPS pre-treatment also inhibited the formation of LiCl-induced taste avoidance, as evidence by significantly higher saccharin preferences in Group LPS–LiCl + Saccharin relative to Group NaCl–LiCl + Saccharin. The results of the current study provide additional evidence for the deleterious effects of LPS on learning and memory in aversive conditioning.
- Subjects :
- Lipopolysaccharides
Male
inorganic chemicals
Taste
Lipopolysaccharide
medicine.medical_treatment
Context (language use)
Pharmacology
Behavioral Neuroscience
chemistry.chemical_compound
Saccharin
Preference test
Avoidance Learning
medicine
Animals
Rats, Long-Evans
Saline
Analysis of Variance
Mouth
Behavior, Animal
Body Weight
Nausea
Fear
Anticipation, Psychological
Rats
Anticipatory nausea
chemistry
Face
Sweetening Agents
Conditioning
Lithium Chloride
psychological phenomena and processes
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....56d960722dfc2cc2cd53172f54a4631d