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Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

Authors :
Helena Cigarrán
María Gómez Martín
José Rozado
Rubén Álvarez-Cabo
Rebeca Lorca
Isaac Pascual
Isabel Rodríguez
Juan Calvo
César Morís
Source :
Scopus, RUO: Repositorio Institucional de la Universidad de Oviedo, Universidad de Oviedo (UNIOVI), RUO. Repositorio Institucional de la Universidad de Oviedo, instname
Publication Year :
2017

Abstract

Bicuspid aortic valve (BAV) or bicuspid aortopathy is the most common congenital heart disease. It can be clinically silent and it is often identified as an incidental finding in otherwise healthy, asymptomatic patients. However, it can be dysfunctioning at birth, even requiring neonatal intervention, or, in time, lead to aortic stenosis, aortic insufficiency, and endocarditis, and also be associated with aortic aneurysm and aortic dissection. Given its prevalence and significant complications, it is estimated that BAV is responsible for more deaths and morbidity than the combined effects of all the other congenital heart defects. Pathology of BAV is still not well known and many questions are unresolved. In this manuscript we review some aspects on bicuspid aortopathy, a heterogeneous and frequent disease in which like some authors have previously described, complex gene environment are present. Further investigations and, what is more, multidisciplinary teams are needed to improve our knowledge on this really fascinating disease.

Details

Database :
OpenAIRE
Journal :
Scopus, RUO: Repositorio Institucional de la Universidad de Oviedo, Universidad de Oviedo (UNIOVI), RUO. Repositorio Institucional de la Universidad de Oviedo, instname
Accession number :
edsair.doi.dedup.....56f2f7d95888dd4f53e91bde8a70ee93