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Cytomegalovirus disease in a retinoblastoma cohort: The role of preemptive screening
- Source :
- Pediatric bloodcancerREFERENCES. 67(3)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND Cytomegalovirus (CMV) disease is underrecognized in children with retinoblastoma. This study investigated rates of CMV infection and disease in this specific population receiving chemotherapy. METHODS From a cohort of 164 patients with retinoblastoma diagnosed from 2011 to 2018, 107 patients were evaluated for CMV infection determined by antigenemia assay or real-time PCR. Preemptive CMV screening was implemented in 2013. CMV disease was diagnosed by tissue biopsy, culture, or ophthalmic examination. RESULTS Thirty-seven and 70 patients before and after the screening strategy, respectively, were included. Before screening, 10/37 (27%) were diagnosed with CMV infection during chemotherapy. Among them, 5 (50%) developed CMV disease (hepatitis, pneumonia, and retinitis) and one patient died of CMV pneumonia. During screening, 18/70 (26%) were documented with 36 episodes of CMV infection and 9 patients received 25 preemptive antiviral therapies. Age at chemotherapy tended to be younger in patients with CMV infection, and fewer were seronegative prior to chemotherapy. Patients who started chemotherapy at
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Retinal Neoplasms
Congenital cytomegalovirus infection
Retinitis
Cytomegalovirus
Disease
Antiviral Agents
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Republic of Korea
Medicine
Humans
Mass Screening
Retrospective Studies
Hepatitis
Chemotherapy
business.industry
Retinoblastoma
Infant, Newborn
virus diseases
Infant
Hematology
medicine.disease
Prognosis
Pneumonia
Oncology
030220 oncology & carcinogenesis
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
Cytomegalovirus Infections
Female
business
030215 immunology
Follow-Up Studies
Subjects
Details
- ISSN :
- 15455017
- Volume :
- 67
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pediatric bloodcancerREFERENCES
- Accession number :
- edsair.doi.dedup.....56f6c3866adf35c0b40abd6b29dd03be